Izvorni znanstveni članak
Treatment of Ocular Motility Disturbances in Graves' Disease with Botulinum Toxin A
Neda Stiglmayer
Mladen Lešin
Jelena Juri
Milan Ivanišević
Lovro Boić
Veljko Rogošić
Sažetak
The aim of this study was to evaluate the efficacy of botulinum toxin-A injections on motility disturbance in patients
with dysthyroid eye disease. In 36 patients (52 orbits) with active phase of Grave’s ophthalmopathy with motility disturbance,
botulinum toxin-A injections were applied. Ocular motility was measured before and after treatment in four
main directions (elevation, depression, abduction and adduction) with Förster perimeter. In all patients 20 units of
botulinum toxin-A in one single injection was applied in the projection of the inferior rectus muscle. Statistically, the
degree of upgaze increased notably in all three groups, but mostly in the first group where it amounted up to 5.8–6.0
(z=10.0; p=0.68). We could not prove notable increase of the motility grade in the adduction in none of the groups of the
tested patients. Due to the fact that eyeball motility can be objectively measured, effect of the applied therapy can be
clearly evaluated.
Ključne riječi
Graves' disease; dysthyroid orbitopathy; botulinum toxin-A; motility disturbance
Hrčak ID:
27911
URI
Datum izdavanja:
20.6.2005.
Posjeta: 1.045 *