Medicina, Vol. 47 No. 2, 2011.
Kratko priopćenje
Isolated intracranial sinus histiocytosis: Report of two cases with Rosai-Dorfman disease
Vili Beroš
; Klinika za neurokirurgiju, KBC Sestre milosrdnice, Zagreb
Karlo Houra
; Odjel za kirurgiju, Opća bolnica Zabok
Hrvoje Čupić
; Klinika za patologiju, KBC Sestre milosrdnice, Zagreb
Darko Stipić
; Klinika za neurokirurgiju, KBC Sestre milosrdnice, Zagreb
Kamelija Žarković
; Klinika za patologiju, CHC Zagreb
Krešimir Rotim
; Klinika za neurokirurgiju, KBC Sestre milosrdnice, Zagreb
Sažetak
Aim: Rosai-Dorfman Disease (RDD) is an idiopathic histiocytic proliferation affecting lymph nodes. Rosai-Dorfman disease rarely affects intracranial structures without involvement of other sites. In this paper we are presenting two cases of RDD with isolated intracranial involvement. Case report: The first patient is a 39-year-old male presenting with an isolated well-circumscribed brain mass in the right temporal lobe, preoperatively thought to be a meningioma. Histological and immunohistochemical analysis confirmed that the lesion was RDD. The intraparenchymal brain location of RDD appears to have a benign course. We also describe the case of 41-year-old man presenting with vertiginous symptoms and mild cerebellar ataxia who was diagnosed with a solitary lesion localised deep in the right cerebellar hemisphere. Immunohistological findings also revealed Rosai-Dorfman disease. Discussion and conclusion: In this paper we are presenting the clinical features, tumor characteristics, differential diagnosis and treatment options. Thorough preoperative evaluation is mandatory and biopsy should be done whenever possible. Surgical treatment of this type of tumour is not always necessary, however, it is essential for postulating the right diagnosis. When total tumor removal is achieved, the outcome is generally better. Recurrence was not observed in our cases where total surgical excision was performed and there was no need for additional therapy. From the clinical point of view RDD might be an important intracerebral entity because it might mimic other lesions, particularly other histiocytic disorders.,îÿÀ
Ključne riječi
central nervous system; intracerebral lesions; Rosai-Dorfman disease; surgery
Hrčak ID:
70143
URI
Datum izdavanja:
1.6.2011.
Posjeta: 2.946 *