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Acta Pharmaceutica, Vol.61 No.4 Prosinac 2011.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-011-0032-4

Sustained release microspheres of ropinirole hydrochloride: Effect of process parameters

AMELIA M. AVACHAT   ORCID icon orcid.org/0000-0003-3127-8067 ; Sinhgad College of Pharmacy, Vadgaon (Bk), Pune-411041 (MS), India
PRALHAD N. BORNARE ; Sinhgad College of Pharmacy, Vadgaon (Bk), Pune-411041 (MS), India
RAKESH R. DASH ; Sinhgad College of Pharmacy, Vadgaon (Bk), Pune-411041 (MS), India

Puni tekst: engleski, pdf (363 KB) str. 363-376 preuzimanja: 1.057* citiraj
APA
AVACHAT, A.M., BORNARE, P.N., DASH, R.R. (2011). Sustained release microspheres of ropinirole hydrochloride: Effect of process parameters. Acta Pharmaceutica, 61(4). doi:10.2478/v10007-011-0032-4

Sažetak
An emulsion solvent evaporation method was employed to prepare microspheres of ropinirole hydrochloride, a highly water soluble drug, by using ethylcellulose and PEG with the help of 32 full factorial design. The microspheres were made by incorporating the drug in a polar organic solvent, which was emulsified using liquid paraffin as an external oil phase. Effects of various process parameters such as viscosity of the external phase, selection of the internal phase, surfactant selection and selection of stirring speed were studied. Microspheres were evaluated for product yield, encapsulation efficiency and particle size. Various drug/ethylcellulose ratios and PEG concentrations were assayed. In vitro dissolution profiles showed that ethylcellulose microspheres were able to control release of the drug for a period of 12 h.

Ključne riječi
ropinirole hydrochloride; microspheres; ethylcellulose; emulsion solvent evaporation; factorial design

Hrčak ID: 71378

URI
http://hrcak.srce.hr/71378

[hrvatski]

Posjeta: 1.260 *