Acta Pharmaceutica, Vol. 61 No. 4, 2011.
Kratko priopćenje
https://doi.org/10.2478/v10007-011-0034-2
Antimicrobial potential of 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives
SONI A. SINGH
; Advanced Research Laboratory in Synthetic and Natural Product Chemistry, V. G. Vaze College, Mumbai University, Mulund (E), Mumbai 400 0081, India
SUJATA V. BHAT
; Advanced Research Laboratory in Synthetic and Natural Product Chemistry, V. G. Vaze College, Mumbai University, Mulund (E), Mumbai 400 0081, India
Sažetak
Twenty Baylis-Hillman adducts were synthesized from different aromatic aldehydes and activated vinyl derivatives. The adducts, which are differently substituted 3-hydroxy-2-methylene-3-phenylpropionic acid derivatives, were screened for their antimicrobial activity in vitro by the serial dilution method. Many of these molecules displayed potent antibacterial and antifungal activities. The ease of synthesis from low-cost starting materials along with potent antimicrobial activity of these molecules provide the lead for further improvement of activity and reflect the possibility of therapeutic use.
Ključne riječi
3-hydroxy-2-methylene-3-phenylpropionic acid derivatives; antibacterial activity; antifungal activity; Baylis-Hillman reaction
Hrčak ID:
71380
URI
Datum izdavanja:
31.12.2011.
Posjeta: 1.563 *