Izvorni znanstveni članak

https://doi.org/10.2478/v10007-012-0025-y

Colon specific delivery of budesonide based on triple coated pellets: In vitro/in vivo evaluation

JALEH VARSHOSAZ ; Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
JABER EMAMI ; Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
NASER TAVAKOLI ; 1Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
MOHSEN MINAIYAN ; Department of Pharmacology, Faculty of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
NAKISA RAHMANI ; Department of Pharmaceutics, Faculty of Pharmacy and Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
FARID DORKOOSH ; Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
PARVIN MAHZOUNI ; Department of Clinical Pathology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Sažetak

Three layered pellets of budesonide were prepared for colon delivery by the extrusion-spheronization method. The coatings consisted of hydroxy propylmethyl cellulose (HPMC) (as barrier layer), Eudragit E (as rate controlling layer) and hydroxy propylmethyl cellulose acetate succinate (HPMC AS) (as enteric layer). The rate controlling layer was further modified using various pore formers. Dissolution studies were carried out at pHs of 1.2, 7.4 and 6.8. Pellet core composition and type and level of pore former affected the drug release from pellets. Pellets containing citric acid 20 % (m/m) in the cores coated with HPMC at a coating level of 6 % (m/m), Eudragit E containing Avicel RC 581 (30 %) as pore former at a coating level of 30 % (m/m) and HPMC AS at a coating level of 15 % (m/m) had the best release profiles. These pellets showed promising results in alleviating the conditions of an experimental model of colitis induced by trinitrobenzenesulfonic acid in rats.

Ključne riječi

colon delivery; three layered pellets; Eudragit E; budesonide; HPMC AS; HPMC

Hrčak ID:

81776

URI

https://hrcak.srce.hr/81776

Datum izdavanja:

30.9.2012.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.884 *