Izvorni znanstveni članak
Optimization of Recipe Based Batch Control Systems Using Neural Networks
A. Šoštarec
; Pliva Croatia Ltd., Prilaz baruna Filipovića 25, Zagreb
D. Gosak
; present address: Hospira Zagreb Ltd., Prilaz baruna Filipovića 27, Zagreb
N. Hlupić
; University of Zagreb, Faculty of Electrical Engineering and Computing, Department of Applied Computing, Unska 3, Zagreb
Sažetak
In the modern pharmaceutical industry many flexible batch plants operate under an integrated business and production system, using ISA S95 and ISA S88 standards for models and terminology, and implementing flexible recipe-based production.
In the environment of constantly changing market conditions, adjustment to surroundings is a business necessity. To support necessary production improvement, regulatory authorities have introduced the risk based approach for the control of process
development, production based on the quality by design (QbD) principle, and process analytical technology (PAT).
In this work, the method for practical implementation of an adaptable control recipe, that allows process improvement inside the previously established design space, is proposed, based on the neural network process model.
Based on the neural network model, the three methods for recipe-controlled process improvement and optimization were introduced – neural-based software sensor, generic neural model control, and process optimization using iterative dynamic programming.
Suitability of the proposed method was tested in a mini reaction plant Chemreactor Büchi, running the wastewater treatment batch, controlled by the production recipe based on S88 standard.
Ključne riječi
ISA S88; neural network model; recipe-controlled process; design space
Hrčak ID:
87350
URI
Datum izdavanja:
3.10.2012.
Posjeta: 1.074 *