Ostalo
HMB-45 Negative Clear Cell Perivascular Epithelioid Cell Tumor of the Skin
Teresa Pusiol
; Institute of Anatomic Pathology Rovereto Hospital Piazza S. Maria 38068 Rovereto (TN) Italy
Doriana Morichetti
; Institute of Anatomic Pathology Rovereto Hospital Piazza S. Maria 38068 Rovereto (TN) Italy
Maria Grazia Zorzi
; Institute of Anatomic Pathology Rovereto Hospital Piazza S. Maria 38068 Rovereto (TN) Italy
Surace Dario
; Institute of Ophthalmology Rovereto Hospital Piazza S. Maria 38068 Rovereto (TN) Italy
Sažetak
The first case of cutaneous clear cell perivascular epithelioid cell
tumor (PEComa) with negative HMB-45 marker is presented. The tumor was a
nodule 3x2 cm in size, located on the right foot in a 60-year-old man. The lesion
consisted of large irregularly shaped cells with clear cytoplasm, negative for
S-100 protein, HMB-45, Melan-A, pancytokeratin, epithelial membrane antigen
and CAM5.2. Multifocal positivity for desmin, microphthalmia transcription
factor and tyrosinase was found. The diagnosis of cutaneous PEComa of clear
cell type was made. Clear cell change is a very unusual finding in PEComa and
may pose problems in diagnostic differentiation from other clear cell cutaneous
lesions that may be excluded with immunohistochemistry. In our case, the
HMB-45 negativity may be explained by extensive clear cell change. Additional
studies are necessary to accept the clear cell cutaneous HMB-45 negative
PEComa as a new variant of perivascular epithelioid cell tumor.
Ključne riječi
perivascular epithelioid cell tumor; clear cell cutaneous tumor; immunohistochemistry
Hrčak ID:
89079
URI
Datum izdavanja:
16.4.2012.
Posjeta: 424 *