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Nuclear translocation of ATBF1 is a potential prognostic maker for skin cancer

Eiichi Nishio ; Nagoya City University
Yutaka Miura ; Nagoya City University
Makoto Kawaguchi ; Niigata Rosai Hospital
Akimichi Morita ; Nagoya City University


Puni tekst: engleski PDF 285 Kb

preuzimanja: 565

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Sažetak

The AT motif binding factor 1 (ATBF1) is expressed in various
tissues, such as brain, liver, lung, and gastrointestinal tract, and has
an important role in cell differentiation in organs. ATBF1 interacts with
PIAS3, a protein inhibitor for activated signal transducer and activator
of transcription (STAT3), to suppress STAT3 signaling, which has critical
roles in cell proliferation, migration, and survival. We hypothesized that
ATBF1 is a useful prognostic marker for skin cancer. We performed immunohistochemical
analyses of squamous cell carcinoma (SCC, n=7),
basal cell carcinoma (BCC, n=4), and Bowen’s disease (n=4) tissues using
an anti-ATBF1 monoclonal antibody. All cases of BCC and Bowen’s
disease exhibited intense nuclear ATBF1 staining, whereas only some
SCC cases exhibited weakly positive nuclear ATBF1 staining. SCC and
Bowen’s disease showed intense nuclear STAT3 staining, while BCC had
few STAT3-positive nuclei. Based on these observations, nuclear ATBF1
staining was associated with low malignancy profiles. The pattern of
ATBF1 staining is a potential prognostic marker for skin cancer.

Ključne riječi

ATBF 1; basal cell carcinoma; Bowen’s disease; squamous cell carcinoma

Hrčak ID:

95693

URI

https://hrcak.srce.hr/95693

Datum izdavanja:

11.1.2013.

Posjeta: 1.067 *