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Acta stomatologica Croatica, Vol.41 No.2 Lipanj 2007.

Izvorni znanstveni članak

Genotoxic Potential of Dentin Bonding Agents

Dunja Prica
Nada Galić
Davor Želježić
Adriana Prica
Sanja Šegović

Puni tekst: engleski, pdf (318 KB) str. 104-114 preuzimanja: 263* citiraj
APA
Prica, D., Galić, N., Želježić, D., Prica, A., Šegović, S. (2007). Genotoxic Potential of Dentin Bonding Agents. Acta stomatologica Croatica, 41(2), 104-114. Preuzeto s http://hrcak.srce.hr/12541
Puni tekst: hrvatski, pdf (318 KB) str. 104-114 preuzimanja: 583* citiraj
APA
Prica, D., Galić, N., Želježić, D., Prica, A., Šegović, S. (2007). Genotoksični potencijal dentinskih adheziva. Acta stomatologica Croatica, 41(2), 104-114. Preuzeto s http://hrcak.srce.hr/12541

Sažetak
The aim of this study was to examine the genotoxic activity of five dentin bonding agents: Adper Single Bond, Adper Single Bond 2, Prompt L-pop, Excite and Opti-Bond Solo Plus. This in vitro study was performed on human lymphocytes from peripheral blood, and the concentrations of dentin bonding agents tested were 0.2, 0.5 i 5 μg/ml, and elution times tested were 1 hour, 24 hours and 5 days. Genotoxicity testing was done using the Structural chromosomal aberration analysis cytogenic method , which determined the complete number of chromosome breaks, chromatide breaks and acentric fragments. The results showed genotoxicity of Opti-Bond Solo Plus in the 0.2 μg/ml concentration after a 24-hour elution period, then OptiBond Solo Plus in the 0.5 μg/ml concentration after a 1 hour elution period and OptiBond Solo Plus, Adper Single Bond 2 and Excite in the 0.5 μg/ml concentration after a 1 day elution period. In the 5 μg/ml concentration after 1 hour of elution, genotoxic potential was observed in cultures with OptiBond Solo Plus, Excite, Adper Single Bond 2 and Adper Single Bond, while all dentin bonding agents showed genotoxicity at that highest concentration but after 1 day of elution. From the results it is obvious that genotoxicity increases with the concentration of the dentin bonding agent, and decreases over time. The highest genotoxicity was observed after a 24-hour-elution period.

Ključne riječi
Mutagens; Dentin-Bonding Agents; Chromosome Aberrations

Hrčak ID: 12541

URI
http://hrcak.srce.hr/12541

[hrvatski]

Posjeta: 1.288 *