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Regularities in Non-crystalline Hydrogen Bonded Systems: Water, Solutions and Biological Macromolecules 30 Years on

John Finney ; ISIS Science Division, Rutherford Appleton Laboratory, Didcot, Oxon, 0X11 OQX. UK
Hugh F. J. Savage ; Chemistry Department, University of York, Heslington, York, YOl 5DD, UK

Sažetak

Major conceptual advances were made by Pauling several decades ago in using information from crystal structures to try to rationalise the structures of apparently complex hydrogen bonded systems. Thus were born not only the a and f structures now recognised as secondary structures in globular proteins, but also reference structures such as the clathrate cage which he used to try to understand the structure of liquid water. Recent developments are discussed which, following the same conceptual approach, have thrown new light on our understanding, not only of the stability of globular proteins, but also of the orientational structure of water at important biomolecular interfaces. The power of the structural regularities uncovered shows that the conceptual approach taken by Pauling in the 1950s retains its power today, and is far from being overshadowed by the impressive numerical work of computational quantum chemists and computer simulators.

Ključne riječi

Hrčak ID:

137309

URI

https://hrcak.srce.hr/137309

Datum izdavanja:

31.12.1991.

Posjeta: 556 *