Medicina, Vol. 52. No. 4., 2016.
Izvorni znanstveni članak
https://doi.org/10.21860/medflum2016_4bil
Risk factors of intraventricular hemorrhage in preterm infants in the Neonatal Intensive Care Unit , University Department of Obstetrics and Gynecology, University Hospital Center Rijeka
Iva Bilić Čače
; Klinika za ginekologiju i porodništvo, KBC Rijeka, Rijeka
Ana Milardović
orcid.org/0000-0002-4692-5821
; Klinika za pedijatriju, KBC Rijeka, Rijeka
Ivana Babić Božović
; Zavod za biologiju i medicinsku genetiku Medicinskog fakulteta Sveučilišta u Rijeci, Rijeka
Maja Kolak
; Klinika za pedijatriju Kliničkog bolničkog centra Rijeka, Rijeka
Sažetak
OBJECTIVE: Intraventricular hemorrhage (IVH) is one of the most important causes of damage to the central nervous system in preterm infants. There are number of the investigated risk factors for IVH in premature infants: genetic, prenatal, delivery factors, and factors related to neonatal period. Some of them are of iatrogenic nature, suggesting the need for scientific-research approach to detect them.
PATIENTS AND METHODS: We retrospectively analyzed data from medical records of Neonatal Intensive Care Unit, at the Department of Obstetrics and Gynecology, University Hospital Center Rijeka. Selected were the data on premature infants who were diagnosed with intraventricular hemorrhage (I- IV. degree), during 2013 and 2014. We analyzed the data of 60 children relating to pregnancy, childbirth and neonatal period. Subjects were divided into groups, depending on the degree of IVH, and the results were statistically analyzed.
RESULTS: Chorioamnionitis during pregnancy, Apgar score at 1st and 5th minutes, perinatal asphyxia, gestational age, the presence of respiratory distress, birth weight, hyper- / hypocapnia, resuscitation, the use of fresh frozen plasma (FFP), sodium bicarbonate (NaHCO3) and the filtered red blood cells (FRBC) in the first week of life, showed a statistically significant association with the development of higher degree IVH. Factors that significantly influenced the degree of IVH are gestational age (P = 0.004) and the application of FE in the first week (P = 0.001). In explaining the degree of IVH, application of FE in the first week of life independently contributed with 11.74%, while gestational age with 7.80%.CONCLUSIONS: It is particularly important that the medical staff, which takes care of preterm newborn and pregnant woman, is familiar with the risk factors for developing IVH, particularly those of iatrogenic nature, for the purpose of their minimization and / or elimination.
Ključne riječi
intraventricular hemorrhage; premature infants; risk factors
Hrčak ID:
168445
URI
Datum izdavanja:
1.12.2016.
Posjeta: 3.206 *