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Acta Pharmaceutica, Vol.67 No.2 Lipanj 2017.

Kratko priopćenje
DOI: 10.1515/acph-2017-0015

Porphyra-334, a mycosporine-like amino acid, attenuates UV-induced apoptosis in HaCaT cells

SUNG-SUK SUH ; Division of Polar Life Sciences, Korea Polar Research Institute, Incheon, 21990, Republic of Korea
SE KYUNG OH ; Division of Polar Life Sciences, Korea Polar Research Institute, Incheon, 21990, Republic of Korea
SUNG GU LEE ; Division of Polar Life Sciences, Korea Polar Research Institute, Incheon, 21990, Republic of Korea; Department of Polar Science, University of Science and Technology, Incheon, 21990, Republic of Korea
IL-CHAN KIM ; Division of Polar Life Sciences, Korea Polar Research Institute, Incheon, 21990, Republic of Korea; Department of Polar Science, University of Science and Technology, Incheon, 21990, Republic of Korea
SANGHEE KIM ; Division of Polar Life Sciences, Korea Polar Research Institute, Incheon, 21990, Republic of Korea; Department of Polar Science, University of Science and Technology, Incheon, 21990, Republic of Korea

Puni tekst: engleski, pdf (2 MB) str. 257-264 preuzimanja: 0* citiraj
APA
SUH, S., OH, S.K., LEE, S.G., KIM, I., KIM, S. (2017). Porphyra-334, a mycosporine-like amino acid, attenuates UV-induced apoptosis in HaCaT cells. Acta Pharmaceutica, 67(2). doi:10.1515/acph-2017-0015

Sažetak
The main aim of the current research was to study the effect of porphyra-334, one of mycosporine-like amino acids (MAAs), well known as UV-absorbing compounds, on UV-induced apoptosis in human immortalized keratinocyte (HaCaT) cells. Due to their UV-screening capacity and ability to prevent UV-induced DNA damage, MAAs have recently attracted considerable attention in both industry and research in pharmacology. Herein, human HaCaT cells were used to determine the biological activities of porphyra-334 by various in vitro assays, including proliferation, apoptosis and Western blot assays. The proliferation rate of UV-irradiated HaCaT cells was significantly decreased compared to the control group. Pretreatment with porphyra-334 markedly attenuated the inhibitory effect of UV and induced a dramatic decrease in the apoptotic rate. Expression of active caspase-3 protein was increased in response to UV irradiation, while caspase-3 levels were similar between cells treated with porphyra-334 and the non-irradiated control group. Taken together, our data suggest that porphyra-334 inhibits UV-induced apoptosis in HaCaT cells through attenuation of the caspase pathway.

Ključne riječi
porphyra-334; apoptosis; cell proliferation; UV irradiation; HaCaT cells

Hrčak ID: 173060

URI
http://hrcak.srce.hr/173060

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