Acta Pharmaceutica, Vol. 54 No. 3, 2004.
Kratko priopćenje
Synthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)- delta2-1,2,4-triazoline-5-thiones
MONIKA WUJEC
MONIKA PITUCHA
MARIA DOBOSZ
URSZULA KOSIKOWSKA
ANNA MALM
Sažetak
In the reaction of hydrazide of thiophene-2-acetic acid (1) with isothiocyanates, the respective thiosemicarbazides 2a-g were obtained. Further cyclization with 2% NaOH led to formation of 4-substituted-3-(thiophene-2-yl-methyl)-delta2-1,2,4-triazoline-5-thiones (3a-g). These compounds showed promising antimycotic activity.
Ključne riječi
4-substituted-3-(thiophene-2-yl-methyl)-delta2-1,2,4-triazoline-5-thiones; synthesis; spectral analysis; antimycotic activity
Hrčak ID:
16868
URI
Datum izdavanja:
1.9.2004.
Posjeta: 2.991 *