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Acta Pharmaceutica, Vol.67 No.3 Rujan 2017.

Izvorni znanstveni članak
DOI: 10.1515/acph-2017-0022

Pharmacokinetic studies and anticancer activity of curcumin-loaded nanostructured lipid carriers

FENGLING WANG   ORCID icon orcid.org/0000-0002-7787-2638 ; Department of Pharmacy, The Second People’s Hospital of Hefei, Hefei 230011, Anhui, People’s Republic of China; Institute of Pharmacokinetics, Anhui University of Chinese Medicine, Hefei 230012, Anhui, People’s Republic of China
JIN CHEN   ORCID icon orcid.org/0000-0002-6607-5705 ; Department of Pharmacy, The Second People’s Hospital of Hefei, Hefei 230011, Anhui, People’s Republic of China
WENTING DAI   ORCID icon orcid.org/0000-0003-1884-6277 ; Department of Pharmacy, The Second People’s Hospital of Hefei, Hefei 230011, Anhui, People’s Republic of China
ZHENGMIN HE   ORCID icon orcid.org/0000-0003-2846-7780 ; Department of Pharmacy, The Second People’s Hospital of Hefei, Hefei 230011, Anhui, People’s Republic of China
DANDAN ZHAI   ORCID icon orcid.org/0000-0003-0865-2364 ; Department of Pharmacy, The Second People’s Hospital of Hefei, Hefei 230011, Anhui, People’s Republic of China
WEIDONG CHEN   ORCID icon orcid.org/0000-0002-7787-2638 ; Institute of Pharmacokinetics, Anhui University of Chinese Medicine, Hefei 230012, Anhui, People’s Republic of China

Puni tekst: engleski, pdf (990 KB) str. 357-371 preuzimanja: 0* citiraj
APA
WANG, F., CHEN, J., DAI, W., HE, Z., ZHAI, D., CHEN, W. (2017). Pharmacokinetic studies and anticancer activity of curcumin-loaded nanostructured lipid carriers. Acta Pharmaceutica, 67(3). doi:10.1515/acph-2017-0022

Sažetak
In order to investigate the potential of nanostructured lipid carriers for efficient and targeted delivery of curcumin, the pharmacokinetic parameters of curcumin-loaded nanostructured lipid carriers (Cur-NLC) were evaluated in rats after a single intraperitoneal dose of Cur-NLC. In addition, the anticancer activity of Cur-NLC against human lung adenocarcinoma A549 cells was verified by a cellular uptake study, and a cytotoxicity and apoptosis assay. Bioavailability of Cur-NLC was better than that of native curcumin (p > 0.01), as seen from the area under the plasma concentration-time curve (AUC), maximum plasma concentration (Cmax), mean residence time (MRT) and total plasma clearance (CLz/F). Cur-NLC has a more obvious lung-targeting property in comparison with native curcumin. Cur-NLC showed higher anticancer activity in vitro against A549 cells than native curcumin (IC50 value of 5.66 vs. 9.81 mg L–1, respectively). Meanwhile, Cur-NLC treated A549 cells showed a higher apoptosis rate compared to that of native curcumin. These results indicate that NLC is a promising system for the delivery of curcumin in the treatment of lung adenocarcinoma.

Ključne riječi
curcumin; nanostructured lipid carriers; pharmacokinetic; anticancer effects; lung adenocarcinoma

Hrčak ID: 181148

URI
http://hrcak.srce.hr/181148

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