Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2017.58.106
Association between metabolically healthy central obesity in women and levels of soluble receptor for advanced glycation end products, soluble vascular adhesion protein-1, and the activity of semicarbazide-sensitive amine oxidase
Ivana Koborová
; Institute of Molecular Biomedicine Faculty of Medicine, Comenius University, Bratislava, Slovakia
Radana Gurecká
; Institute of Molecular Biomedicine Faculty of Medicine, Comenius University, Bratislava, Slovakia
Melinda Csongová
; Institute of Molecular Biomedicine Faculty of Medicine, Comenius University, Bratislava, Slovakia
Katarína Volkovová
; Institute of Biology, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia
Éva Szökő
; Department of Pharmacodynamics, Faculty ofPharmacy, Semmelweis University,Budapest, Hungary
Tamás Tábi
; Department of Pharmacodynamics, Faculty ofPharmacy, Semmelweis University,Budapest, Hungary
Katarína Šebeková
; Institute of Molecular Biomedicine Faculty of Medicine, Comenius University, Bratislava, Slovakia
Sažetak
Aim To determine the levels of circulating soluble receptor
for advanced glycation end products (sRAGE), as a biomarker
of risk of metabolic syndrome and cardiovascular
disease development in centrally obese (CO) women considered
metabolically healthy (COH) in comparison with
those metabolically unhealthy (COU).
Methods 47 lean healthy, 17 COH (presenting waist-toheight
ratio ≥0.5 but not elevated blood pressure, atherogenic
lipid profile, and insulin resistance), and 50 COU (CO
presenting ≥2 risk factors) women aged 40-45 years were
included. Anthropometric characteristics, blood chemistry
and hematology data, adipokines, markers of inflammation,
sRAGE, soluble vascular adhesion protein-1 (sVAP-1),
and the activity of semicarbazide sensitive amine oxidase
(SSAO) were determined.
Results Central obesity associated with low sRAGE levels
(lean healthy: 1503 ± 633 pg/mL; COH: 1103 ± 339 pg/mL,
P < 0.05; COU: 1106 ± 367 ng/mL, P < 0.0.1), hyperleptinemia,
and elevated markers of inflammation irrespective of
the presence or absence of cardiometabolic risk factors.
COU women presented high adiponectin levels. SVAP-1
concentrations and the activity of SSAO were similar in all
3 groups.
Conclusion COH women present abnormalities in nonstandard
markers of cardiometabolic risk (sRAGE, leptin,
high sensitive C-reactive protein), supporting the view
that there is no healthy pattern of obesity. The clinical impact
of our findings for future prognosis of metabolically
healthy obese subjects remains to be elucidated in longitudinal
studies.
Ključne riječi
Hrčak ID:
181576
URI
Datum izdavanja:
15.4.2017.
Posjeta: 1.073 *