Izvorni znanstveni članak
The influence of chelating agents on uranium retention in the kidney
Krista Kostial
; Institut za medicinska istraživanja i medicinu rada, Zagreb
Kata Voloder
; Institut za medicinska istraživanja i medicinu rada, Zagreb
V.B. Vouk
; Institut za medicinska istraživanja i medicinu rada, Zagreb
O. Weber
; Institut za medicinska istraživanja i medicinu rada, Zagreb
Sažetak
In rats treated with uranyl nitrate (7,6 mg per kilogramme of body weight) 28 per cent of the applied dose was found in the kidney three hours after the intraperitoneal injection. In animals receiving diethylenetriamine penta-acetic acid (DTP A) by intraperitoneal injection (1 mM per kilogramme of body weight) immediately after the treatment with uranyl nitrate a significant reduction of the uranium content of the kidneys was observed. Only 12 per cent of the injected dose was found in the kidneys. The application of hydroxydiphenylether phosphate (HDPP), however, caused the opposite effect, resulting in a 55 per cent retention of uranium by the kidney. The possible mechanism of this action is discussed
Ključne riječi
Hrčak ID:
181664
URI
Datum izdavanja:
14.12.1962.
Posjeta: 720 *