Izvorni znanstveni članak
Tetanus in P.R. Croatia from the epidemiological and clinical point of view
B. Bezjak
; Bolnica za zarazne bolesti, Zagreb
J. Fališevac
; Bolnica za zarazne bolesti, Zagreb
Sažetak
Yugoslavia is an agricultural country and tetanus is of great importance in the national pathology since:
1. it has one of the highest mortality rates among acute infectious diseases,
2. the disease has a fatality rate of 43% and
3. it has shown a steady increase during the last years.
This paper presents an analysis of 360 cases of tetanus which were treated in the Fever Hospital, Zagreb, from 1939-1954 (table 1). This analysis is intended to show the epidemiological and' clinical aspects of tetanus in P.R. Croatia and other parts of Yugoslavia. The highest regional incidence of tetanus is in the northern agricultural parts of Yugoslavia. In the great majority of cases (78%) it is a disease of peasants and their children. Among inhabitants·of towns it is a disease of those from the peripheral parts who are occupied with some agricultural work as well. Industrial workers and some tradesmen (joiners, tailors, shoemakers etc.) also suffer from tetanus (table 4). Tetanus has a characteristic seasonal incidence and the great majority of cases occurs between May and October (table 2) i. e. in the season when people do agricultural work in fields and gardens (table 3). It is of great importance that most of our peasants work bare-footed on manured soil. Tetanus very often occurs among newborns and younger age groups (from 6-20 years of age). In this age group the occurrence is more common in males than females (126:53) because of the much greater exposure to injuries of male youth during their work, play and sport (table 5). In 47,51% of cases the type of injury was a puncture (table 6) with different instruments (thorn, wooden splinter etc. - table 7). The most common site of injury was the foot (table 11). Modern concepts of pathogenesis of tetanus are briefly described. Most of our cases of tetanus presented themselves as a generalised tetanus (table 8) of moderate severity, whereas there were only a few cases of localised tetanus, all of them mild. The number of cases of tetanus in the newborn is small because these cases have been admitted to our hospital only since 1952. The number of cases of gynaecological tetanus is also small; this is probably due to the unreliable data. The .case fatality rate depended on the clinical form of the disease and was the highest in the cephalic and gynaecological forms and in tetanus of the newborn (table 9). Clinical relation of fatality rate to incubation period (table 10), location of injury (table 11) and interval between the first signs of tetanus and first spasms (table 12) is analysed. The average fatality rate in the analysed material was 30,55%. The treatment of tetanus is discussed in more detail. Since 1953 all moderate and severe cases of tetanus were given muscle relaxant Tolserol beside the usual therapy (antitoxic serum. hypnotics, narcotics, antibiotics etc.). The best results with this drug have been achieved in moderately severe cases as regards the subjective state of the patients, by facilitating the intake of food and fluids. In some patients with retention of urine this condition was overcome by the drug. In most of the severe cases, however, Tolserol was not able to control reflex spasms and save the life of the patient. In cases with spasm of the pharyngeal muscles we have also used a gastric tube for feeding and drug administration. The tube was maintained in position for a period of several days. In two cases with chronic tetanus satisfactory therapeutic result has been obtained with active immunisation. Seroprophylaxis and active immunisation against tetanus are briefly discussed. Active immunisation of people most exposed to infection with tetanus is recommended.
Ključne riječi
Hrčak ID:
186445
URI
Datum izdavanja:
14.6.1955.
Posjeta: 923 *