Pregledni rad
https://doi.org/10.26332/seemedj.v1i1.33
A Cross-Talk between the Renin-Angiotensin and Adrenergic Systems in Cardiovascular Health and Disease
Ana Stupin
; Department of Physiology and Immunology, Faculty of Medicine Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Ines Drenjancevic
; Department of Physiology and Immunology, Faculty of Medicine Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Lidija Rasic
; Department of Physiology and Immunology, Faculty of Medicine Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Anita Cosic
; Department of Physiology and Immunology, Faculty of Medicine Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Marko Stupin
; Department of Physiology and Immunology, Faculty of Medicine Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department for Cardiovascular Diseases, Osijek University Hospital, Osijek, Croatia
Sažetak
It is well accepted that a number of cardiovascular (CV) and renal diseases are characterized by the
long-term activation of both the renin-angiotensin system (RAS) and the sympathetic nervous system
(SNS), which also contribute to the pathophysiology of structural and functional CV abnormalities as
well as to the final clinical outcome. Moreover, there is a growing body of conclusive evidence that
these systems do not operate independently, but interact at different levels throughout the CV
system. The mediation of renin release from juxtaglomerular epithelioid (JGE) cells in kidney by SNS
is well established and accepted. On the other hand, in recent years it became evident that RAS, by
its main effect or angiotensin II (Ang II), induces SNS activity in various organs and tissues. Thus, there
is a growing effort to clarify pathophysiological mechanisms of interaction and a more evident mutual
potentiation of these two systems in different pathological states. Since it became evident that a high
salt (HS) intake, which is a major risk factor for hypertension development, has a deleterious impact
on vascular and endothelial functions (even in the absence of blood pressure changes), it became
necessary to investigate and clarify the effect of HS loading on major regulating systems—RAS and
SNS—precisely in healthy individuals. The present review aimed to summarize the interactions
between the RAS and SNS in health and diseases (e.g. cardiovascular, renal), with a special focus on
these two systems’ interaction during HS intake in a healthy normotensive population.
Ključne riječi
renin-angiotensin system; sympathetic nervous system; cardiovascular function; chronic heart failure; chronic kidney disease; salt intake
Hrčak ID:
186755
URI
Datum izdavanja:
3.7.2017.
Posjeta: 1.398 *