Pregledni rad
Inflammatory Bowel Diseases
Boris Vucelić
Silvija Čuković-Čavka
Sažetak
The chronic infl ammatory bowel diseases
(IBD) are idiopathic, infl ammatory chronic diseases of the gastrointestinal
tract, unpredictable in the course. Epidemiological
data show a rise in the incidence and suggest that both environmental
and genetic infl uences are involved in the pathogenesis
of chronic infl ammatory bowel diseases. Laboratory data suggest
that the disease is a result of aberrant mucosal immune
response in genetically susceptible individuals. NOD2/CARD15
has been identifi ed as a fi rst gene defi nitely linked to Crohn’s
disease. Crohn’s disease is characterised by patchy transmural
infl ammation affecting any part of the gastrointestinal tract,
whereas ulcerative colitis characteristically is limited to the
colon, producing continuous mucosal infl ammation always
involving the rectum. Extra-intestinal manifestations affecting
the skin, joints, and the eyes occur in both Crohn’s disease
and ulcerative colitis. The current treatment of Crohn’s disease
and ulcerative colitis comprises a combination of medical (aminosalicylates,
corticosteroids, antibiotics, immunosuppressive
agents, biologicals – infl iximab only registered and clinically
available) and surgical therapy.
Ključne riječi
inflammatory bowel diseases (IBD); ulcerative colitis; Crohn’s disease; genetics; NOD2/CARD15; aminosalicylates; corticosteroids; immunomodulators; infliximab
Hrčak ID:
18859
URI
Datum izdavanja:
26.1.2006.
Posjeta: 12.774 *