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https://doi.org/10.2478/v1007-008-0005-4

Anti-inflammatory and analgesic activities of some newly synthesized pyridinedicarbonitrile and benzopyranopyridine derivatives

HANAA M. HOSNI ; Pesticide Chemistry Department, National Research Centre, Doki, Cairo, Egypt
MOHAMED M. ABDULLA ; Research Units, Hi-Care Pharmaceutical Co., Cairo, Egypt


Puni tekst: engleski pdf 85 Kb

str. 175-186

preuzimanja: 1.426

citiraj


Sažetak

In continuation of our search for new substituted pyridine based anti-inflammatories, reaction of 1-(2-thienyl or furanyl)-3-(2-hydroxyphenyl)-2-propen-1-ones (1) with malononitrile in alcoholic KOH solution afforded a mixture of 4-alkoxy-2-(2-thienyl or furanyl)-5H-[1]benzopyrano[3,4-c]pyridine-5-ones (2) and 2-alkoxy-4-amino-6-(2-thienyl or furanyl)-3,5-pyridinedicarbonitriles (3). Some of the synthesized compounds were evaluated for their anti-inflammatory and analgesic activities compared to diclofenac potassium as positive control. Detailed synthesis, spectroscopic and toxicity data are reported.

Ključne riječi

pyridinedicarbonitrile; benzopyranopyridine; anti-inflammatrory; analgesic agents

Hrčak ID:

21366

URI

https://hrcak.srce.hr/21366

Datum izdavanja:

1.6.2008.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.376 *