Izvorni znanstveni članak
Diagnostic Value of Thyrotropin Releasing Hormone Test in 129 Patients with Suspected Tumoral Hyperprolactinemia
L. Smirčić-Duvnjak
B. Vizner
M. Koršić
M. Sekso
M. Berković
Sažetak
In 129 hyperprolactinemic (PRL 100ng/mL) and 100 normoprolactinemic patients
(PRL 0–25 ng/mL), max. PRL (the difference between maximal prolactin (PRL) after
thyrotropin releasing hormone (TRH) injection and basal value) was compared with
basal PRL and computed tomography (CT) of the sellar region. In 122 hyperprolactinemic
patients max. PRL was <100%, while tumor was found in 106 of them. In the remainder
seven hyperprolactinemic patients max. PRL was 100% and CT showed no
tumor. A significant difference in max. PRL between hyperprolactinemic patients
without and those with verified adenoma was found and showed a significant negative
correlation with basal PRL. Between 122 hyperprolactinemic patients with max. PRL
<100%, mean basal PRL and duration of clinical symptoms were significantly lower in
16 patients with normal CT compared to 106 patients with tumor. All normoprolactinemic
patients showed max. PRL 100% and no tumor on CT. PRL stimulation disturbance
precedes tumor visualization and represents a decisive diagnostic parameter in
hyperprolactinemic patients with no tumor signs.
Ključne riječi
Hrčak ID:
28310
URI
Datum izdavanja:
16.12.2002.
Posjeta: 1.015 *