Acta Pharmaceutica, Vol. 58 No. 4, 2008.
Izvorni znanstveni članak
https://doi.org/10.2478/v10007-008-0030-3
The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities
RAFAT M. MOHAREB
; Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
KARAM A. El-SHARKAWY
; Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), October, A. R. Egypt
SHERIF M. SHERIF
; Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
Sažetak
Condensation of β-amino-α,γ-dicyanocrotononitrile (1) with acetophenone gave the 2-amino-4-phenylpenta-1,3-diene-1,1,3-tricarbonitrile (2). The latter product was used in a series of heterocyclization reactions when react with different reagents like diazonium salts, hydrazines, hydroxylamine and elemental sulfur to give pyridazine, pyrazole, isoxazole and thiophene derivatives, respectively. On the other hand, it gave pyridine derivatives with aromatic aldehydes followed by reaction with cyanomethylene reagents. The MIC values for the newly synthesized product were measured against E. coli, B. cereus, B. subtilis and C. albicans
Ključne riječi
pyridine; isoxazole; pyridazine; thiophene; antimicrobial activity
Hrčak ID:
28934
URI
Datum izdavanja:
1.12.2008.
Posjeta: 2.328 *