Kratko priopćenje

https://doi.org/10.2478/v10007-009-0002-2

Hepatoprotective effects of Calotropis gigantea extract against carbon tetrachloride induced liver injury in rats

GAURAV LODHI ; 1Department of Pharmacology and Therapeutics, Chatrapati Sahuji Maharaj Medical University, Lucknow, India-226003
HEMANT KUMAR SINGH ; Hygia Institute of Pharmaceutical Education and Research, Faizullahganj, Lucknow, India-226020
KAMLESH K. PANT ; 1Department of Pharmacology and Therapeutics, Chatrapati Sahuji Maharaj Medical University, Lucknow, India-226003
ZEASHAN HUSSAIN ; Hygia Institute of Pharmaceutical Education and Research, Faizullahganj, Lucknow, India-226020

Sažetak

Ethanolic extract (50 %) of stems of Calotropis gigantea R. Br. (Asclepiadaceae) at doses of 250 and 500 mg kg1 were studied for hepatoprotective activity in male Wistar rats with liver damage induced using carbon tetrachloride, 2 mL kg-1 twice a week. The protective effect of C. gigantea extract was compared with the standard drug silymarin. Various biochemical parameters such as aspartate amino transferase (AST), alanine amino transferase (ALT), glutathione (GSH), lipid peroxide (LPO), superoxidedismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were evaluated. The results revealed that the C. gigantea extract significantly decreased AST, ALT (p < 0.001) and lipid peroxide (p < 0.01) levels. The antioxidant parameters GSH, GPx, SOD and catalase levels were increased considerably compared to the levels in groups treated with carbon tetrachloride only

Ključne riječi

Calotropis gigantea (Asclepiadaceae); hepatoprotective activity; serum enzymes; antioxidants

Hrčak ID:

31145

URI

https://hrcak.srce.hr/31145

Datum izdavanja:

1.3.2009.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.628 *