Izlaganje sa skupa

SMOKING AND SCHIZOPHRENIA

Marina Šagud ; University Department, Clinical Hospital Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia
Alma Mihaljević-Peleš ; University Department, Clinical Hospital Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia
Dorotea Mück-Šeler ; Ruđer Bošković Institute, Zagreb, Croatia
Nela Pivac ; Ruđer Bošković Institute, Zagreb, Croatia
Bjanka Vuksan-Ćusa ; University Department, Clinical Hospital Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia
Tomo Brataljenović ; University Department, Clinical Hospital Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia
Miro Jakovljević ; University Department, Clinical Hospital Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia

Sažetak

Smoking prevalence for schizophrenic patients is higher than this for general population. More than 60% of schizophrenic patients are current smokers, which contributes to excessive mortality in these patients.
The reasons for high frequency of both smoking prevalence and heavy smoking in schizophrenic patients is thought to be at least partially related to enhancement of brain dopaminergic activity, which, in turn, results in behavioral reinforcement due
to stimulant effects. Smoking stimulates dopaminergic activity in the brain by inducing its release and inhibiting its degradation. There is also evidence that cigarette smoking can reduce deficits relative to dopamine hypofunction in prefrontal cortex. Recent neuroimaging studies have further contributed the evidence of complex influences of cigarette smoking on brain dopaminergic function. It has been suggested that smoking may be an attempt by schizophrenic
patients to alleviate cognitive deficits and to reduce extrapyramidal side-effects induced by antipsychotic medication. Cigarette smoke also increases the activity of CYP 1A2 enzymes, thus decreasing the concentration of many drugs, including clozapine and olanzapine. There is also evidence that smoking is associated with increased clearance of tiotixene, fluphenazine and haloperidol. Given the high
frequency of smoking in schizophrenic patients, clinicians need to check smoking status in each patient.
Schizophrenic patients who smoke may require higher dosages of antipsychotics than nonsmokers. Conversely, upon smoking cessation, smokers may require a reduction in the dosage of antipsychotics.

Ključne riječi

schizophrenia; smoking

Hrčak ID:

49292

URI

https://hrcak.srce.hr/49292

Datum izdavanja:

25.6.2009.

Posjeta: 3.936 *