Izvorni znanstveni članak
Value of Fine-Needle Aspiration Cytology in Diagnosis of Hodgkin’s Lymphoma and Anaplastic Large Cell Lymphoma: One Centre Experience
Slobodanka Ostojić Kolonić
; Department of Medicine, University Hospital »Merkur«, Zagreb, Croatia
Katja Prašek-Kudrna
; University of Zagreb, School of Medicine, Zagreb, Croatia
Vinko Roso
; University of Zagreb, School of Medicine, Zagreb, Croatia
Delfa Radić-Krišto
; Department of Medicine, University Hospital »Merkur«, Zagreb, Croatia
Ana Planinc-Peraica
; Department of Medicine, University Hospital »Merkur«, Zagreb, Croatia
Sonja Džebro
; Department of Pathology and Cytology, University Hospital »Merkur«, Zagreb, Croatia
Ika Kardum-Skelin
; University of Zagreb, School of Medicine, Zagreb, Croatia
Branimir Jakšić
; Department of Medicine, University Hospital »Merkur«, Zagreb, Croatia
Sažetak
The aim of the study was to determine the value and limitations of cytology in diagnosis of Hodgkin’s lymphoma (HL) and anaplastic large cell lymphoma (ALCL) as well as differentiation between these two entities. We analysed the FNA cytodiagnoses and histopathological reports, as well as treatment and survival in 89 newly diagnosed consecutive patients with these lymphomas treated in our clinical department. These patients (40 male, 49 female; age range 16–93 years; 44 in clinical stages I–II; 38 with B symptoms) were diagnosed and treated during a period of 64 months (1.1. 2004–1.5.2009). The FNA cytodiagnoses were available in 86 patients and the pathohistological diagnoses were available in 84 patients. Cytology revealed 65 classic HL, 18 ALCL and three patients in which diagnosis was not informative. Among 65 FNA cytodiagnoses of HL, comparison with histopathology was made in 61 cases and the histopathological diagnoses were as follows: 56 (91.8%) HL; three ALCL; one diffuse large B cell lymphoma and one marginal zone B cell lymphoma. In the group of 18 FNA cytodiagnoses of ALCL eight patients (53.3%) had definitive diagnosis of ALCL (either as T-cell or O type), five (33.3%) of HL and in three cases a histopathological diagnosis could not be made. These results confirm the value of FNA in diagnostic procedure in patients with HL and ALCL, especially in HL group of patients. Since we have an almost uniform group of patients according to therapeutic approach, we did univariate analyses and found out that patients with FNA cytodiagnoses of HL, younger than 55 years, with early stage of the disease and without B symptoms had significantly longer overall survival (OS). FNA cytodiagnosis has clinical relevance in differentiation between HL and ALCL.
Ključne riječi
fine-needle aspiration cytology; Hodgkin’s lymphoma; anaplastic large cell lymphoma
Hrčak ID:
51245
URI
Datum izdavanja:
10.3.2010.
Posjeta: 1.580 *