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Reactivity of Acetates in Aqueous Alcohols

Bernard Denegri ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000 Zagreb, Croatia
Olga Kronja ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000 Zagreb, Croatia


Puni tekst: engleski pdf 2.046 Kb

str. 223-226

preuzimanja: 920

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Sažetak

A series of X,Y-substituted benzhydryl acetates (1-3) were subjected to solvolysis in various binary methanol/water and ethanol/water mixtures at 25 °C. The LFER equation log k = sf(Ef + Nf) was used
to derive the nucleofuge-specific parameters (Nf and sf) for an SN1 type reaction in 60 % and 80 % aqueous methanol. It has been established that X,Y-substituted benzhydryl acetates produce almost parallel correlation lines, so the average sf = 0.9 has been taken for calculation of the nucleofugality parameters
from a single rate constant in some solvent mixtures. In comparison with other leaving groups for which
the nucleofugality has already been determined, acetates are the poorest nucleofuges.

Ključne riječi

acetate; nucleofugality; electrofugality; solvolysis; nucleophilic substitution

Hrčak ID:

56026

URI

https://hrcak.srce.hr/56026

Datum izdavanja:

15.7.2010.

Posjeta: 1.604 *