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The Antimetastatic Effect of Macrophages Restored by Indomethacin: Concomitant Tumor Immunity Model

Marija Kušan Jukić
Ana Tikvica Luetić
Vesna Škudar-Lukinović
Igor Andreis


Puni tekst: engleski pdf 78 Kb

str. 899-904

preuzimanja: 394

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Sažetak

The role of macrophages acting as immunologic antitumor effectors and promoters of tumor growth are poorly understood as yet. We investigated the role of macrophage in model of concomitant immunity (CI), a phenomenon of secondary tumor rejection during the primary tumor growth. It has been shown that the period of CI weakening can coincide with appearance of tumor metastases. We used mammary carcinoma (MC) artificial lung metastases to evaluate the influence of macrophages from various period of CI on the development of metastases in mice. Our results indicated that macrophages are responsible for the late period of CI weakening and suppression. To investigate weather prostaglandins can mediate suppressive effect of macrophages we used experiments with indomethacin and we found that inhibition of prostaglandin E2 synthesis by indomethacin restored antimetastatic effect of concomitant immune macrophages.

Ključne riječi

macrophages; concomitant immunity; mammary carcinoma; prostaglandins

Hrčak ID:

59327

URI

https://hrcak.srce.hr/59327

Datum izdavanja:

1.10.2010.

Posjeta: 983 *