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Collegium Antropologicum, Vol.34 No.3 Listopad 2010.
Prethodno priopćenje
Drug-Induced Aseptic Meningitis, Sensorineural Hearing Loss and Vestibulopaty
Juraj Sepčić
Mira Bučuk
Olivio Perković
Dubravka Šepić-Grahovac
Biserka Trošelj-Vukić
Ivica Poljak
Marija Crnić-Martinović
Iztok Turel
Smiljana Ristić
Kristina Sepčić
Puni tekst: pdf (58 KB),
Engleski,
Str. 1101 - 1104
,
Sažetak
We report clinically rare and serious adverse reactions that occurred after the co-administration of ranitidine, ibuprofen and ciprofloxacin: completely reversible aseptic meningitis and irreversible bilateral sensorineural hearing loss, tinnitus, and vestibulopathy. Recurrent urinary inflammations treated with antibacterials, classic familial migraine, and allergy to trimethoprim-sulfamethoxazole and chromium were favourable predisposing factors for the adverse event in this patient. A close chronological relation between administration of drugs (especially ibuprofen) and adverse reactions was noted. No evidence of infection and/or autoimmune disease was found. The mechanism of these serious events may be explained as a hypersensitive reaction affecting the meninges and, partially, cochlea.
Ključne riječi
ranitidine, ibuprofen, ciprofloxacin, drug interactions, aseptic meningitis, deafness
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