Medicina, Vol. 46 No. 4, 2010.
Pregledni rad
Does the changes in the plasma lipoproteins concentration influence the onset of coronary artery calcifications in the patients with end-stage renal failure?
Petar Kes
; Zavod za nefrologiju, arterijsku hipertenziju i dijalizu, Klinika za unutarnje bolesti, Klinički bolnički centar Zagreb, Zagreb
Nikolina Bašić-Jukić
; Zavod za nefrologiju, arterijsku hipertenziju i dijalizu, Klinika za unutarnje bolesti, Klinički bolnički centar Zagreb, Zagreb
Ivana Jurić
; Zavod za nefrologiju, arterijsku hipertenziju i dijalizu, Klinika za unutarnje bolesti, Klinički bolnički centar Zagreb, Zagreb
Sažetak
Atherosclerosis is a systemic disease that is the leading cause of death in the developed
world and leads to coronary artery, carotid artery, and peripheral arterial atherosclerotic
syndromes. The pathophysiology of atherosclerosis is known to be dependent on multiple hereditary
and environmental factors. Loss of normal endothelial function is a fundamental step
in the atherosclerotic disease process. A consistent body of evidence from large clinical trails
suggests that qualitative changes in plaques contribute importantly to the striking reduction in
clinical events produced by lipid lowering. Calcium mineral deposits that frequently accompany
atherosclerosis are readily quantifiable radiographically, serve as a surrogate marker for the
disease, and predict a higher risk of myocardial infarction and death. Coronary artery calcification
is a common observation in chronic kidney disease and end-stage renal disease and is
mainly related to age, duration on dialysis, and dyslipidemia. The annual progression of coronary
artery calcification can be reduced from 30 % to 6 % with LDL cholesterol reduction
caused by statins and possibly sevelamer. At treated LDL cholesterol levels somewhere below
2.59 mmol/l, several sources of data suggest that the anatomic burden of coronary artery disease,
including coronary artery calcification, regresses. Additional supportive studies indicate
that carotid intima media thickness and the volume of coronary atheroma can also be reduced
by LDL cholesterol reduction in concert with elevation of HDL cholesterol.
Ključne riječi
atherosclerosis; cholesterol; coronary artery calcification; end-stage renal disease; plaque
Hrčak ID:
63071
URI
Datum izdavanja:
8.12.2010.
Posjeta: 2.238 *