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Review article
https://doi.org/10.2478/acph-2013-0026

Methods of amorphization and investigation of the amorphous state

TOMAŽ EINFALT ; University of Ljubljana, Faculty of Pharmacy, 1000 Ljubljana, Slovenia
ODON PLANINŠEK ; University of Ljubljana, Faculty of Pharmacy, 1000 Ljubljana, Slovenia
KLEMEN HROVAT ; University of Ljubljana, Faculty of Pharmacy, 1000 Ljubljana, Slovenia

Fulltext: english, pdf (1 MB) pages 305-334 downloads: 4.403* cite
APA 6th Edition
EINFALT, T., PLANINŠEK, O. & HROVAT, K. (2013). Methods of amorphization and investigation of the amorphous state. Acta Pharmaceutica, 63 (3), 305-334. https://doi.org/10.2478/acph-2013-0026
MLA 8th Edition
EINFALT, TOMAŽ, et al. "Methods of amorphization and investigation of the amorphous state." Acta Pharmaceutica, vol. 63, no. 3, 2013, pp. 305-334. https://doi.org/10.2478/acph-2013-0026. Accessed 22 Aug. 2019.
Chicago 17th Edition
EINFALT, TOMAŽ, ODON PLANINŠEK and KLEMEN HROVAT. "Methods of amorphization and investigation of the amorphous state." Acta Pharmaceutica 63, no. 3 (2013): 305-334. https://doi.org/10.2478/acph-2013-0026
Harvard
EINFALT, T., PLANINŠEK, O., and HROVAT, K. (2013). 'Methods of amorphization and investigation of the amorphous state', Acta Pharmaceutica, 63(3), pp. 305-334. https://doi.org/10.2478/acph-2013-0026
Vancouver
EINFALT T, PLANINŠEK O, HROVAT K. Methods of amorphization and investigation of the amorphous state. Acta Pharm. [Internet]. 2013 [cited 2019 August 22];63(3):305-334. https://doi.org/10.2478/acph-2013-0026
IEEE
T. EINFALT, O. PLANINŠEK and K. HROVAT, "Methods of amorphization and investigation of the amorphous state", Acta Pharmaceutica, vol.63, no. 3, pp. 305-334, 2013. [Online]. https://doi.org/10.2478/acph-2013-0026

Abstracts
The amorphous form of pharmaceutical materials represents the most energetic solid state of a material. It provides advantages in terms of dissolution rate and bioavailability. This review presents the methods of solid-state amorphization described in literature (supercooling of liquids, milling, lyophilization, spray drying, dehydration of crystalline hydrates), with the emphasis on milling. Furthermore, we describe how amorphous state of pharmaceuticals differ depending on method of preparation and how these differences can be screened by a variety of spectroscopic (X-ray powder diffraction, solid state nuclear magnetic resonance, atomic pairwise distribution, infrared spectroscopy, terahertz spectroscopy) and calorimetry methods.

Keywords
amorphous solid preparation; crystallinity; spectroscopy; calorimetry

Hrčak ID: 102052

URI
https://hrcak.srce.hr/102052

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