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Izvorni znanstveni članak
https://doi.org/10.5599/admet.2.1.33

The intrinsic aqueous solubility of indomethacin

John Comer ; Sirius Analytical Ltd., Forest Row, West Sussex RH18 5DW, UK
Sam Judge ; Sirius Analytical Ltd., Forest Row, West Sussex RH18 5DW, UK
Darren Matthews ; Sirius Analytical Ltd., Forest Row, West Sussex RH18 5DW, UK
Louise Towes ; Sirius Analytical Ltd., Forest Row, West Sussex RH18 5DW, UK
Bruno Falcone ; Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
Jonathan Goodman ; Unilever Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
John Dearden ; School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK

Puni tekst: engleski, pdf (915 KB) str. 18-32 preuzimanja: 3.231* citiraj
APA 6th Edition
Comer, J., Judge, S., Matthews, D., Towes, L., Falcone, B., Goodman, J. i Dearden, J. (2014). The intrinsic aqueous solubility of indomethacin. ADMET and DMPK, 2 (1), 18-32. https://doi.org/10.5599/admet.2.1.33
MLA 8th Edition
Comer, John, et al. "The intrinsic aqueous solubility of indomethacin." ADMET and DMPK, vol. 2, br. 1, 2014, str. 18-32. https://doi.org/10.5599/admet.2.1.33. Citirano 16.09.2019.
Chicago 17th Edition
Comer, John, Sam Judge, Darren Matthews, Louise Towes, Bruno Falcone, Jonathan Goodman i John Dearden. "The intrinsic aqueous solubility of indomethacin." ADMET and DMPK 2, br. 1 (2014): 18-32. https://doi.org/10.5599/admet.2.1.33
Harvard
Comer, J., et al. (2014). 'The intrinsic aqueous solubility of indomethacin', ADMET and DMPK, 2(1), str. 18-32. https://doi.org/10.5599/admet.2.1.33
Vancouver
Comer J, Judge S, Matthews D, Towes L, Falcone B, Goodman J i sur. The intrinsic aqueous solubility of indomethacin. ADMET and DMPK [Internet]. 2014 [pristupljeno 16.09.2019.];2(1):18-32. https://doi.org/10.5599/admet.2.1.33
IEEE
J. Comer, et al., "The intrinsic aqueous solubility of indomethacin", ADMET and DMPK, vol.2, br. 1, str. 18-32, 2014. [Online]. https://doi.org/10.5599/admet.2.1.33

Sažetak
A value of 8.8 μg/mL was measured for the intrinsic solubility of indomethacin. Evidence of a form with a solubility of about 77 μg/mL was also obtained. Solubility measurements were conducted using the CheqSol and Curve Fitting methods using a maximum pH of 9. It is also demonstrated that a published intrinsic solubility of 410 μg/mL was in error due to decomposition of indomethacin at pH 12. The decomposition of indomethacin at pH 12 was investigated. Decomposition products comprising p-chlorobenzoic acid and 5-Methoxy-2-methyl-3-indoleacetic acid were isolated and characterised.

Ključne riječi
Indomethacin; solubility; CheqSol; p-chlorobenzoic acid; decomposition

Hrčak ID: 119017

URI
https://hrcak.srce.hr/119017

Posjeta: 3.556 *