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Review article

Alternative Models for Toxicity Testing of Xenobiotics

Jasna Kniewald
Ivana Kmetič
Višnja Gaurina-Srček
Zlatko Kniewald

Fulltext: english, pdf (91 KB) pages 195-204 downloads: 1.482* cite
APA 6th Edition
Kniewald, J., Kmetič, I., Gaurina-Srček, V. & Kniewald, Z. (2005). Alternative Models for Toxicity Testing of Xenobiotics. Arhiv za higijenu rada i toksikologiju, 56 (2), 195-204. Retrieved from https://hrcak.srce.hr/149
MLA 8th Edition
Kniewald, Jasna, et al. "Alternative Models for Toxicity Testing of Xenobiotics." Arhiv za higijenu rada i toksikologiju, vol. 56, no. 2, 2005, pp. 195-204. https://hrcak.srce.hr/149. Accessed 13 May 2021.
Chicago 17th Edition
Kniewald, Jasna, Ivana Kmetič, Višnja Gaurina-Srček and Zlatko Kniewald. "Alternative Models for Toxicity Testing of Xenobiotics." Arhiv za higijenu rada i toksikologiju 56, no. 2 (2005): 195-204. https://hrcak.srce.hr/149
Harvard
Kniewald, J., et al. (2005). 'Alternative Models for Toxicity Testing of Xenobiotics', Arhiv za higijenu rada i toksikologiju, 56(2), pp. 195-204. Available at: https://hrcak.srce.hr/149 (Accessed 13 May 2021)
Vancouver
Kniewald J, Kmetič I, Gaurina-Srček V, Kniewald Z. Alternative Models for Toxicity Testing of Xenobiotics. Arh Hig Rada Toksikol. [Internet]. 2005 [cited 2021 May 13];56(2):195-204. Available from: https://hrcak.srce.hr/149
IEEE
J. Kniewald, I. Kmetič, V. Gaurina-Srček and Z. Kniewald, "Alternative Models for Toxicity Testing of Xenobiotics", Arhiv za higijenu rada i toksikologiju, vol.56, no. 2, pp. 195-204, 2005. [Online]. Available: https://hrcak.srce.hr/149. [Accessed: 13 May 2021]

Abstracts
The alternatives to whole-animal testing include endpoint assays, cell and tissue cultures, use of tissue slices, toxicokinetic modelling, and structure-activity relationships and databases. The use of in vitro systems (subcellular fractions, cell lines, primary cell cultures, tissue slices, organ cultures, etc.) as research tools in toxicology is widespread. In the past few years, the apoptosis phenomena were followed by very precise intracellular changes where, through programmed cell death, a cell can be removed from a population. The in vitro systems are ideally suited for investigations of the molecular, cellular and physiological mechanisms of chemically induced toxicity, which cannot readily be studied in vivo for known target organ and target species toxicity studies and for answering specific questions about toxic effects. The main justification for developing in vitro toxicity tests is that they will make toxicology a more scientifically based practice. It is increasingly apparent that the development and incorporation of stepwise testing strategies, combining experimental data from a range of alternative methods (physicochemical techniques, quantitative structure-activity relationships - QSAR, metabolic and kinetic modelling and in vitro tests), provide the most advanced way to predict toxicity, reducing at the same time the number of laboratory animals used for testing.

Keywords
alternative methods; biomarkers; in vitro methods; predicting toxic hazard; validation

Hrčak ID: 149

URI
https://hrcak.srce.hr/149

[croatian]

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