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Original scientific paper

Toxic effects of Ustilago maydis and fumonisin B1 in rats

STJEPAN PEPELJNJAK
JÓZSEF PETRIK
MAJA ŠEGVIĆ KLARIĆ

Fulltext: english, pdf (83 KB) pages 339-348 downloads: 631* cite
APA 6th Edition
PEPELJNJAK, S., PETRIK, J. & ŠEGVIĆ KLARIĆ, M. (2005). Toxic effects of Ustilago maydis and fumonisin B1 in rats. Acta Pharmaceutica, 55 (4), 339-348. Retrieved from https://hrcak.srce.hr/18117
MLA 8th Edition
PEPELJNJAK, STJEPAN, et al. "Toxic effects of Ustilago maydis and fumonisin B1 in rats." Acta Pharmaceutica, vol. 55, no. 4, 2005, pp. 339-348. https://hrcak.srce.hr/18117. Accessed 19 Oct. 2019.
Chicago 17th Edition
PEPELJNJAK, STJEPAN, JÓZSEF PETRIK and MAJA ŠEGVIĆ KLARIĆ. "Toxic effects of Ustilago maydis and fumonisin B1 in rats." Acta Pharmaceutica 55, no. 4 (2005): 339-348. https://hrcak.srce.hr/18117
Harvard
PEPELJNJAK, S., PETRIK, J., and ŠEGVIĆ KLARIĆ, M. (2005). 'Toxic effects of Ustilago maydis and fumonisin B1 in rats', Acta Pharmaceutica, 55(4), pp. 339-348. Available at: https://hrcak.srce.hr/18117 (Accessed 19 October 2019)
Vancouver
PEPELJNJAK S, PETRIK J, ŠEGVIĆ KLARIĆ M. Toxic effects of Ustilago maydis and fumonisin B1 in rats. Acta Pharm. [Internet]. 2005 [cited 2019 October 19];55(4):339-348. Available from: https://hrcak.srce.hr/18117
IEEE
S. PEPELJNJAK, J. PETRIK and M. ŠEGVIĆ KLARIĆ, "Toxic effects of Ustilago maydis and fumonisin B1 in rats", Acta Pharmaceutica, vol.55, no. 4, pp. 339-348, 2005. [Online]. Available: https://hrcak.srce.hr/18117. [Accessed: 19 October 2019]

Abstracts
Ustilago maydis and FB1 showed neurotoxicity in Fischer rats, which was indicated by hyperactivity, brain hyperaemia and especially by decreased AChE activity. These pathological changes could be related to the alkaloids of U. maydis and disruption of sphingolipid metabolism by FB1 activity. Pathological changes in liver, lungs, uterus and ovaries were more pronounced in the US+FB1 than in the US group, indicating possible synergism. Increased activity of LDH in the serum was observed only in the US+FB1 group, which led to the conclusion that FB1 is responsible for cytotoxic effects. Such activity of FB1 could increase the toxicity of U. maydis and other co-contaminants of fungal origin that can be found in foods and feeds.

Keywords
Ustilago maydis; fumonisin B1; neurotoxycity; cytotoxicity

Hrčak ID: 18117

URI
https://hrcak.srce.hr/18117

[croatian]

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