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Original scientific paper
https://doi.org/10.5562/cca3111

Synthesis, Antimicrobial Activities of New Sulfonamidobenzoxazoles and Molecular Docking Studies on Escherichia coli TEM-1 β-Lactamase

Tugba Ertan-Bolelli ; Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Ankara, Turkey
Kayhan Bolelli ; Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Ankara, Turkey
Suzan Okten ; Department of Pharmaceutical Microbiology, Trakya University, Faculty of Pharmacy, Edirne, Turkey
Fatma Kaynak-Onurdag ; Department of Pharmaceutical Microbiology, Trakya University, Faculty of Pharmacy, Edirne, Turkey
Esin Aki-Yalcin ; Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Ankara, Turkey
Ismail Yalcin ; Department of Pharmaceutical Chemistry, Ankara University, Faculty of Pharmacy, Ankara, Turkey

Fulltext: english, pdf (1 MB) pages 67-74 downloads: 782* cite
APA 6th Edition
Ertan-Bolelli, T., Bolelli, K., Okten, S., Kaynak-Onurdag, F., Aki-Yalcin, E. & Yalcin, I. (2017). Synthesis, Antimicrobial Activities of New Sulfonamidobenzoxazoles and Molecular Docking Studies on Escherichia coli TEM-1 β-Lactamase. Croatica Chemica Acta, 90 (1), 67-74. https://doi.org/10.5562/cca3111
MLA 8th Edition
Ertan-Bolelli, Tugba, et al. "Synthesis, Antimicrobial Activities of New Sulfonamidobenzoxazoles and Molecular Docking Studies on Escherichia coli TEM-1 β-Lactamase." Croatica Chemica Acta, vol. 90, no. 1, 2017, pp. 67-74. https://doi.org/10.5562/cca3111. Accessed 18 May 2021.
Chicago 17th Edition
Ertan-Bolelli, Tugba, Kayhan Bolelli, Suzan Okten, Fatma Kaynak-Onurdag, Esin Aki-Yalcin and Ismail Yalcin. "Synthesis, Antimicrobial Activities of New Sulfonamidobenzoxazoles and Molecular Docking Studies on Escherichia coli TEM-1 β-Lactamase." Croatica Chemica Acta 90, no. 1 (2017): 67-74. https://doi.org/10.5562/cca3111
Harvard
Ertan-Bolelli, T., et al. (2017). 'Synthesis, Antimicrobial Activities of New Sulfonamidobenzoxazoles and Molecular Docking Studies on Escherichia coli TEM-1 β-Lactamase', Croatica Chemica Acta, 90(1), pp. 67-74. https://doi.org/10.5562/cca3111
Vancouver
Ertan-Bolelli T, Bolelli K, Okten S, Kaynak-Onurdag F, Aki-Yalcin E, Yalcin I. Synthesis, Antimicrobial Activities of New Sulfonamidobenzoxazoles and Molecular Docking Studies on Escherichia coli TEM-1 β-Lactamase. Croatica Chemica Acta [Internet]. 2017 [cited 2021 May 18];90(1):67-74. https://doi.org/10.5562/cca3111
IEEE
T. Ertan-Bolelli, K. Bolelli, S. Okten, F. Kaynak-Onurdag, E. Aki-Yalcin and I. Yalcin, "Synthesis, Antimicrobial Activities of New Sulfonamidobenzoxazoles and Molecular Docking Studies on Escherichia coli TEM-1 β-Lactamase", Croatica Chemica Acta, vol.90, no. 1, pp. 67-74, 2017. [Online]. https://doi.org/10.5562/cca3111

Abstracts
β-Lactam antibiotics are frequently used for treatment of multi-drug resistant microbial infections and the most common mechanism of resistance against these antibiotics is bacterial β-lactamase production. Herein, we reported the design, synthesis and in vitro antimicrobial activities of some new 2-substituted-5-(2,4-dinitrophenylsulfonamido)benzoxazole derivatives. Compounds TN1, TN2, and TN3 were found to be significantly active against E. coli isolate which contains extended spectrum β-lactamase enzyme at the MIC value of 8 µg mL–1 and that is
4-fold higher than the reference drug ampicillin. We performed molecular docking studies into active site of Escherichia coli TEM-1 β-lactamase enzyme in order to predict the protein-ligand interactions. According to the docking results, compounds TN1, TN2, and TN3 showed strong interactions between the important active site residues which are responsible for the catalytic mechanism of TEM-1 β-lactamase enzyme and a good correlation is found with the experimental data.

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords
antimicrobial activity; benzoxazole; Escherichia coli; β-lactamase; molecular docking; sulfonamide

Hrčak ID: 182676

URI
https://hrcak.srce.hr/182676

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