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Aromatic Phosphoryl Thiocholines. II. Syntheses and Physicochemical Properties

M. Ćosić ; Institute for Technical and Medical Protection, 11000 Belgrade, Serbia
M. Orlov ; Institute for Technical and Medical Protection, 11000 Belgrade, Serbia
Z. Binenfeid ; Institute for Technical and Medical Protection, 11000 Belgrade, Serbia

Sažetak

The synthesis of seven undescribed 0-ethyl-S-[(2-N-methyl-
N-arylamino)ethyl] methylphosphonothioates (compounds I-VII)
and their methosulphates (compounds VIII-XIV) is presented
together with their physicochemical characteristics.
From N,N-dimethylarylamines were prepared N-methyl-N-(
2-hydroxyethyl)arylamines which with phosphorus oxychloride
gave the corresponding N-methyl,N-(2-chloroethyl)arylamines. By
reacting them with sodium 0-ethyl methylphosphonothioate the substances I-VII were obtained. The substances VIII-XIV were
obtained by quaternization of substance I-VII with dimethylsulphate.
As intermediate products the following new compounds were
1synthetized: N-methyl- N-(2-hydroxyethyl)m-methoxyphenylamine,
N-methyl- N-(2-hydroxyethyl)p-methoxyphenylamine, N-methylN-(
2-chloroethyl)m-methoxyphenylamine and N-methyl- N-(2-
-chloroethyl)p-methoxyphenylamine.

Ključne riječi

Hrčak ID:

197004

URI

https://hrcak.srce.hr/197004

Datum izdavanja:

15.4.1974.

Posjeta: 445 *