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https://doi.org/10.2478/acph-2022-0002

Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons

JINGJING TAN ; Department of Anesthesia and Perioperative Medicine, Shanghai Fourth People's Hospital, Affiliated to Tongji University, Shanghai 200081 China
MANOJ KUMAR YADAV ; Department of Pharmacology, Swift School of Pharmacy, Ghaggar Sarai, Rajpura (Patiala) Punjab – 140401, India
SUSHMA DEVI orcid id orcid.org/0000-0002-4449-9072 ; Department of Pharmacology, Swift School of Pharmacy, Ghaggar Sarai, Rajpura (Patiala) Punjab – 140401, India
MANISH KUMAR orcid id orcid.org/0000-0001-6697-544X ; Department of Pharmacology, Swift School of Pharmacy, Ghaggar Sarai, Rajpura (Patiala) Punjab – 140401, India; Chitkara College of Pharmacy, Chitkara University, Rajpura (Patiala) Punjab – 140401, India


Puni tekst: engleski pdf 1.624 Kb

str. 123-134

preuzimanja: 82

citiraj


Sažetak

In this study, the neuroprotective potential of arbutin (100 µmol L–1) pre-treatment and post-treatment against oxygen/glucose deprivation (OGD) and reoxygenation (R) induced ischemic injury in cultured rat cortical neurons was explored. The OGD (60 min) and reoxygenation (24 h) treatment significantly (p < 0.001) compromised the antioxidant defence in cultured neurons. Subsequently, an increase (p < 0.001) in lipid peroxidation and inflammatory cytokines (tumour necrosis factor-α and nuclear factor kappa-B) declined neuron survival. In pre- and post-condition experiments, treatment with arbutin enhanced both survival (p < 0.01) and integrity (p < 0.05) of cultured neurons. Results showed that arbutin protects (p < 0.05) against peroxidative changes, inflammation, and enhanced the antioxidant activity (e.g., glutathione, superoxide dismutase and catalase) in cultured neurons subjected to OGD/R. It can be inferred that arbutin could protect against ischemic injuries and stroke. The anti-ischemic activity of arbutin can arrest post-stroke damage to the brain.

Ključne riječi

arbutin, cerebral ischemia, inflammation, oxidative stress

Hrčak ID:

253968

URI

https://hrcak.srce.hr/253968

Posjeta: 175 *