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Acta Pharmaceutica, Vol. 59 No. 2, 2009

Original scientific paper
https://doi.org/10.2478/v10007-009-0019-6

Development and evaluation of gastroretentive norfloxacin floating tablets

RAMESH BOMMA ; University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009 (A.P.), India
RONGALA APPALA SWAMY NAIDU ; Natco Pharma Ltd., Kotthur, Mahaboobnagar District, India
MADHUSUDAN RAO YAMSANI ; University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009 (A.P.), India
KISHAN VEERABRAHMA ; University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009 (A.P.), India

Fulltext: english, pdf (99 KB) pages 211-221 downloads: 1.928* cite
APA 6th Edition
BOMMA, R., NAIDU, R.A.S., YAMSANI, M.R. & VEERABRAHMA, K. (2009). Development and evaluation of gastroretentive norfloxacin floating tablets. Acta Pharmaceutica, 59 (2), 211-221. https://doi.org/10.2478/v10007-009-0019-6
MLA 8th Edition
BOMMA, RAMESH, et al. "Development and evaluation of gastroretentive norfloxacin floating tablets." Acta Pharmaceutica, vol. 59, no. 2, 2009, pp. 211-221. https://doi.org/10.2478/v10007-009-0019-6. Accessed 22 Apr. 2019.
Chicago 17th Edition
BOMMA, RAMESH, RONGALA APPALA SWAMY NAIDU, MADHUSUDAN RAO YAMSANI and KISHAN VEERABRAHMA. "Development and evaluation of gastroretentive norfloxacin floating tablets." Acta Pharmaceutica 59, no. 2 (2009): 211-221. https://doi.org/10.2478/v10007-009-0019-6
Harvard
BOMMA, R., et al. (2009). 'Development and evaluation of gastroretentive norfloxacin floating tablets', Acta Pharmaceutica, 59(2), pp. 211-221. doi: https://doi.org/10.2478/v10007-009-0019-6
Vancouver
BOMMA R, NAIDU RAS, YAMSANI MR, VEERABRAHMA K. Development and evaluation of gastroretentive norfloxacin floating tablets. Acta Pharm. [Internet]. 2009 [cited 2019 April 22];59(2):211-221. doi: https://doi.org/10.2478/v10007-009-0019-6
IEEE
R. BOMMA, R.A.S. NAIDU, M.R. YAMSANI and K. VEERABRAHMA, "Development and evaluation of gastroretentive norfloxacin floating tablets", Acta Pharmaceutica, vol.59, no. 2, pp. 211-221, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0019-6

Abstracts
Floating matrix tablets of norfloxacin were developed to prolong gastric residence time, leading to an increase in drug bioavailability. Tablets were prepared by the wet granulation technique, using polymers such as hydroxy propyl methylcellulose (HPMCK4M, HPMCK100M) and xanthan gum. Tablets were evaluated for their physical characteristics viz., hardness, thickness, friability, and mass variation, drug content and floating properties. Further, tablets were studied for in vitro drug release characteristics for 9 hours. The tablets exhibited controlled and prolonged drug release profiles while floating over the dissolution medium. Non-Fickian diffusion was confirmed as the drug release mechanism from these tablets, indicating that water diffusion and the polymer rearrangement played an essential role in drug release. The best formulation (F4) was selected based on in vitro characteristics and was used in vivo radiographic studies by incorporating BaSO4. These studies revealed that the tablets remained in the stomach for 180 ± 30 min in fasting human volunteers and indicated that gastric retention time was increased by the floating principle, which was considered desirable for absorption window drugs.

Keywords
norfloxacin; floating tablets; gastric residence time; gastroretentive drug delivery system

Hrčak ID: 36096

URI
https://hrcak.srce.hr/36096

[croatian]

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