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Acta Pharmaceutica, Vol. 59 No. 3, 2009

Original scientific paper
https://doi.org/10.2478/v10007-009-0024-9

Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques

RENU CHADHA ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
POONAM ARORA ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
RUPINDER KAUR ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
ANUPAM SAINI ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
MADAN LAL SINGLA ; Central Scientific Instruments Organization, Sector-30/C, Chandigarh-16003, India
DHARAMVIR SINGH JAIN ; Department of Chemistry, Panjab University, Chandigarh-160014, India

Fulltext: english, pdf (321 KB) pages 245-257 downloads: 1.063* cite
APA 6th Edition
CHADHA, R., ARORA, P., KAUR, R., SAINI, A., SINGLA, M.L. & JAIN, D.S. (2009). Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques. Acta Pharmaceutica, 59 (3), 245-257. https://doi.org/10.2478/v10007-009-0024-9
MLA 8th Edition
CHADHA, RENU, et al. "Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques." Acta Pharmaceutica, vol. 59, no. 3, 2009, pp. 245-257. https://doi.org/10.2478/v10007-009-0024-9. Accessed 23 Apr. 2019.
Chicago 17th Edition
CHADHA, RENU, POONAM ARORA, RUPINDER KAUR, ANUPAM SAINI, MADAN LAL SINGLA and DHARAMVIR SINGH JAIN. "Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques." Acta Pharmaceutica 59, no. 3 (2009): 245-257. https://doi.org/10.2478/v10007-009-0024-9
Harvard
CHADHA, R., et al. (2009). 'Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques', Acta Pharmaceutica, 59(3), pp. 245-257. doi: https://doi.org/10.2478/v10007-009-0024-9
Vancouver
CHADHA R, ARORA P, KAUR R, SAINI A, SINGLA ML, JAIN DS. Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques. Acta Pharm. [Internet]. 2009 [cited 2019 April 23];59(3):245-257. doi: https://doi.org/10.2478/v10007-009-0024-9
IEEE
R. CHADHA, P. ARORA, R. KAUR, A. SAINI, M.L. SINGLA and D.S. JAIN, "Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques", Acta Pharmaceutica, vol.59, no. 3, pp. 245-257, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0024-9

Abstracts
Identification and characterization of different forms of methotrexate were carried out by crystallization from different solvents. Five different forms of the drug were obtained. Appearance of a desolvation endotherm in the DSC accompanied by mass loss in TGA for forms I, II, IV and V showed these forms to be acetonitrile solvate hydrate (form I), trihydrate (forms II and IV) and dimethylformamide solvate (form V), respectively. However, the desolvation peak was absent in form III (obtained from methanol) indicating the absence of any solvent of crystallization. This form was found to be partially crystalline by its XRPD pattern. Solution calorimetry was further used to differentiate between the forms as they differ in lattice energy, resulting in different enthalpies of solution. The dissolution and solubility profiles were correlated with the enthalpy of solution and subsequently with crystallinity of all the forms; the least endothermic form (form III) had the highest dissolution rate.

Keywords
solvatomorph; pseudopolymorph; methotrexate; enthalpy of solution; solution calorimetry; desolvation; dissolution rate

Hrčak ID: 38924

URI
https://hrcak.srce.hr/38924

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