Izvorni znanstveni članak
The Effects of Long-Term Experimental Diabetes Mellitus Type I on Skeletal Muscle Regeneration Capacity
Romana Jerković
; Department of Anatomy, School of Medicine, University of Rijeka, Rijeka, Croatia
Alan Bosnar
; Department of Forensic Medicine, School of Medicine, University of Rijeka, Rijeka, Croatia
Dubravka Jurišić-Eržen
; Department of Internal Medicine, Clinical Hospital Centre Rijeka, Rijeka, Croatia
Josip Ažman
; Department of Anatomy, School of Medicine, University of Rijeka, Rijeka, Croatia
Gordana Starčević-Klasan
; Department of Anatomy, School of Medicine, University of Rijeka, Rijeka, Croatia
Stanislav Peharec
; Polyclinic of Physical Medicine and Rehabilitation, Pula, Croatia
Miran Čoklo
; Department of Forensic Medicine, School of Medicine, University of Rijeka, Rijeka, Croatia
Sažetak
Muscle fibers are dynamic structures capable of altering their phenotype under various pathological conditions. The aim of the present study was to investigate the influence of long-lasting diabetes mellitus on the process of muscle regeneration in the skeletal muscle. Wistar rats were made diabetic by a single intraperitoneal injection of streptozotocin (STZ). The regeneration process in the skeletal muscle was induced in slow (m. soleus, SOL) and fast (m. extensor digitorum longus, EDL) muscles by injection of local anesthetic (bupivacaine). Skeletal muscles were analyzed 10 days, 4 and 8 weeks after bupivacaine treatment. Diabetes mellitus has changed morphological properties of both slow and fast skeletal muscles during the process of regeneration. These changes are evident in redistribution of muscle fibers and significant level of atrophy. All fiber types of diabetic fast muscles showed stronger atrophy than muscle fibers in slow muscles which have more oxidative metabolism. The changes of redistribution of muscle fibers depend on duration of diabetes and affect all types of muscle fibers.
Ključne riječi
skeletal muscle; regeneration; type 1 diabetes mellitus; atrophy; rat
Hrčak ID:
51468
URI
Datum izdavanja:
1.12.2009.
Posjeta: 1.001 *