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Original scientific paper

Effect of Botulinum Toxin-A Injection on Intraocular Pressure and Proptosis in Thyroid Associated Orbitopathy

Mladen Lešin ; Eye Department, University Hospital Center Split, Split, Croatia
Lovro Bojić ; Eye Department, University Hospital Center Split, Split, Croatia
Rinaldo Romac ; Department of Neurology, University Hospital Center Split, Split, Croatia
Joško Leštin ; Department of Obstetrics and Gynecology, School of Medicine, University of Zagreb, Zagreb, Croatia
Milan Ivanišević ; Eye Department, University Hospital Center Split, Split, Croatia
Davor Galetović ; Eye Department, University Hospital Center Split, Split, Croatia
Veljko Rogošić ; Eye Department, University Hospital Center Split, Split, Croatia

Fulltext: english, pdf (52 KB) pages 1155-1161 downloads: 336* cite
APA 6th Edition
Lešin, M., Bojić, L., Romac, R., Leštin, J., Ivanišević, M., Galetović, D. & Rogošić, V. (2009). Effect of Botulinum Toxin-A Injection on Intraocular Pressure and Proptosis in Thyroid Associated Orbitopathy. Collegium antropologicum, 33 (4), 1155-1161. Retrieved from https://hrcak.srce.hr/51483
MLA 8th Edition
Lešin, Mladen, et al. "Effect of Botulinum Toxin-A Injection on Intraocular Pressure and Proptosis in Thyroid Associated Orbitopathy." Collegium antropologicum, vol. 33, no. 4, 2009, pp. 1155-1161. https://hrcak.srce.hr/51483. Accessed 19 Sep. 2021.
Chicago 17th Edition
Lešin, Mladen, Lovro Bojić, Rinaldo Romac, Joško Leštin, Milan Ivanišević, Davor Galetović and Veljko Rogošić. "Effect of Botulinum Toxin-A Injection on Intraocular Pressure and Proptosis in Thyroid Associated Orbitopathy." Collegium antropologicum 33, no. 4 (2009): 1155-1161. https://hrcak.srce.hr/51483
Harvard
Lešin, M., et al. (2009). 'Effect of Botulinum Toxin-A Injection on Intraocular Pressure and Proptosis in Thyroid Associated Orbitopathy', Collegium antropologicum, 33(4), pp. 1155-1161. Available at: https://hrcak.srce.hr/51483 (Accessed 19 September 2021)
Vancouver
Lešin M, Bojić L, Romac R, Leštin J, Ivanišević M, Galetović D, et al. Effect of Botulinum Toxin-A Injection on Intraocular Pressure and Proptosis in Thyroid Associated Orbitopathy. Collegium antropologicum [Internet]. 2009 [cited 2021 September 19];33(4):1155-1161. Available from: https://hrcak.srce.hr/51483
IEEE
M. Lešin, et al., "Effect of Botulinum Toxin-A Injection on Intraocular Pressure and Proptosis in Thyroid Associated Orbitopathy", Collegium antropologicum, vol.33, no. 4, pp. 1155-1161, 2009. [Online]. Available: https://hrcak.srce.hr/51483. [Accessed: 19 September 2021]

Abstracts
The aim of this study was to evaluate the effects of extraocular muscle injection of botulinum toxin-A (BTX-A) on intraocular pressure (IOP) and proptosis in patients with ocular motility disturbances in thyroid associated orbitopathy (TAO). In 17 patients (20 eyes) with restrictive strabismus and diplopia, BTX -A injections were applied. Intraocular pressure was measured with a Goldmann applanation tonometer in primary gaze position before and 2–4 weeks after BTX-A injection. Extraorbital prominention of the eyeball was measured before and after BTX -A injection using a Hertel instrument. Before the injection, the mean IOP in primary position of gaze was 18.6± 2.8 mmHg and 2–4 weeks after BTX-A injection was 16.9±3.3 mmH; (p=0.001). There was no statistically significant difference in Hertel egzophthalmometer readings before and after BTX-A injection, 21.5±2.7 mm vs 22.0± 2.6 mm; (p=0.678). In conclusion, BTX-A injection has a secondary lowering effect on IOP in TAO due to relaxation of extraocular muscles, but with no influence on proptosis.

Keywords
thyroid related orbitopathy; botulinum toxin-A; intraocular pressure; proptosis

Hrčak ID: 51483

URI
https://hrcak.srce.hr/51483

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