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Acta Pharmaceutica, Vol. 61 No. 1, 2011

Short communication, Note
https://doi.org/10.2478/v10007-011-0003-9

Development and evaluation of in situ novel intragastric controlled-release formulation of hydrochlorothiazide

RAVIKUMAR R. PATEL ; Jodhpur National University, Jodhpur, Rajshathan, India
JAYVADAN K. PATEL ; Department of Pharmaceutical Technology Nootan Pharmacy College, Visnagar-384315 (GUJ), India

Fulltext: english, pdf (100 KB) pages 73-82 downloads: 454* cite
APA 6th Edition
PATEL, R.R. & PATEL, J.K. (2011). Development and evaluation of in situ novel intragastric controlled-release formulation of hydrochlorothiazide. Acta Pharmaceutica, 61 (1), 73-82. https://doi.org/10.2478/v10007-011-0003-9
MLA 8th Edition
PATEL, RAVIKUMAR R. and JAYVADAN K. PATEL. "Development and evaluation of in situ novel intragastric controlled-release formulation of hydrochlorothiazide." Acta Pharmaceutica, vol. 61, no. 1, 2011, pp. 73-82. https://doi.org/10.2478/v10007-011-0003-9. Accessed 20 Apr. 2019.
Chicago 17th Edition
PATEL, RAVIKUMAR R. and JAYVADAN K. PATEL. "Development and evaluation of in situ novel intragastric controlled-release formulation of hydrochlorothiazide." Acta Pharmaceutica 61, no. 1 (2011): 73-82. https://doi.org/10.2478/v10007-011-0003-9
Harvard
PATEL, R.R., and PATEL, J.K. (2011). 'Development and evaluation of in situ novel intragastric controlled-release formulation of hydrochlorothiazide', Acta Pharmaceutica, 61(1), pp. 73-82. doi: https://doi.org/10.2478/v10007-011-0003-9
Vancouver
PATEL RR, PATEL JK. Development and evaluation of in situ novel intragastric controlled-release formulation of hydrochlorothiazide. Acta Pharm. [Internet]. 2011 [cited 2019 April 20];61(1):73-82. doi: https://doi.org/10.2478/v10007-011-0003-9
IEEE
R.R. PATEL and J.K. PATEL, "Development and evaluation of in situ novel intragastric controlled-release formulation of hydrochlorothiazide", Acta Pharmaceutica, vol.61, no. 1, pp. 73-82, 2011. [Online]. doi: https://doi.org/10.2478/v10007-011-0003-9

Abstracts
In situ forming intragastric controlled-release formulation is a new technology in the field of oral controlled release delivery systems. The objective of this study was to develop the formulations that can control drug release up to 24 hours. In addition, a combination of appropriate polymers and solvents was selected that could form a drug loaded gel at the process temperature of 60–70 °C, which could turn into a rigid mass upon exposure to dissolution fluid at body temperature. The drug release mechanism from this rigid mass was controlled by different formulation factors such as different polymer grades, polymer concentrations, hydrophobicity or hydrophilicity of solvents, different drug loadings, and physicochemical properties of additional excipients. After evaluating different formulation factors, Ethocel 10 FP and triethyl citrate were selected for further studies using hydrochlorothiazide as a model drug. Polynomial correlation between viscosity of the blank gel and drug release profile was also obtained.

Keywords
physical compatibility; hydrochlorothiazide; polymer grade; drug loaded gel; polmer concentration

Hrčak ID: 63374

URI
https://hrcak.srce.hr/63374

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