Kratko priopćenje

https://doi.org/10.2478/v10007-011-0014-6

Synthesis, antispasmodic and antidiarrheal activities of some 1-substituted imidazole derivatives

BASKAR LAKSHMANAN ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand-835215, India
PAPIYA MITRA MAZUMDER ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand-835215, India
DINAKAR SASMAL ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand-835215, India
SWASTIKA GANGULY ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi, Jharkhand-835215, India

Sažetak

A series of 1-substituted imidazoles 1a-d and 2a-d were synthesized and screened for antispasmodic and antidiarrheal activities. Antispasmodic activity was tested at various concentrations on isolated tissue preparations; concentration-response curves were plotted and compared with atropine. All compounds were found to inhibit contraction of the guinea pig ileum. Castor oil-induced diarrhea model in rats was used for evaluation of antidiarrheal activity. Parameters such as intestinal transit and volume of intestinal fluid were measured for antidiarrheal activity at 40 mg kg-1 dose and compared with the standard drug loperamide at a 6 mg kg1 dose. Defecation frequency in the test group was found to be significantly lower (p < 0.01) compared to the control group and comparable with that of the standard. The present study reveals that the compounds exert antidiarrheal activity through possible inhibition of intestinal movement and reduction of capillary permeability in the abdominal cavity.

Ključne riječi

1-substituted imidazoles; antispasmodic; antidiarrheal; gastro-intestinal transit

Hrčak ID:

66185

URI

https://hrcak.srce.hr/66185

Datum izdavanja:

1.6.2011.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.290 *