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Acta Pharmaceutica, Vol. 61 No. 2, 2011

Short communication, Note
https://doi.org/10.2478/v10007-011-0016-4

Compatibility studies of nateglinide with excipients in immediate release tablets

NIHAR RANJAN PANI ; Department of Pharmaceutical Technology, Gayatri College of Pharmacy, Sambalpur, Odisha-768200, India
LILA KANTA NATH ; Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh Assam-786004, India
SUJATA ACHARYA ; University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Orissa, India

Fulltext: english, pdf (174 KB) pages 237-247 downloads: 2.176* cite
APA 6th Edition
PANI, N.R., NATH, L.K. & ACHARYA, S. (2011). Compatibility studies of nateglinide with excipients in immediate release tablets. Acta Pharmaceutica, 61 (2), 237-247. https://doi.org/10.2478/v10007-011-0016-4
MLA 8th Edition
PANI, NIHAR RANJAN, et al. "Compatibility studies of nateglinide with excipients in immediate release tablets." Acta Pharmaceutica, vol. 61, no. 2, 2011, pp. 237-247. https://doi.org/10.2478/v10007-011-0016-4. Accessed 25 Apr. 2019.
Chicago 17th Edition
PANI, NIHAR RANJAN, LILA KANTA NATH and SUJATA ACHARYA. "Compatibility studies of nateglinide with excipients in immediate release tablets." Acta Pharmaceutica 61, no. 2 (2011): 237-247. https://doi.org/10.2478/v10007-011-0016-4
Harvard
PANI, N.R., NATH, L.K., and ACHARYA, S. (2011). 'Compatibility studies of nateglinide with excipients in immediate release tablets', Acta Pharmaceutica, 61(2), pp. 237-247. doi: https://doi.org/10.2478/v10007-011-0016-4
Vancouver
PANI NR, NATH LK, ACHARYA S. Compatibility studies of nateglinide with excipients in immediate release tablets. Acta Pharm. [Internet]. 2011 [cited 2019 April 25];61(2):237-247. doi: https://doi.org/10.2478/v10007-011-0016-4
IEEE
N.R. PANI, L.K. NATH and S. ACHARYA, "Compatibility studies of nateglinide with excipients in immediate release tablets", Acta Pharmaceutica, vol.61, no. 2, pp. 237-247, 2011. [Online]. doi: https://doi.org/10.2478/v10007-011-0016-4

Abstracts
Experiments were done to assess the compatibility of nateglinide with selected excipients in the development of immediate release tablets of nateglinide by thermal and isothermal stress testing (IST) techniques. To evaluate the drug-excipient compatibility, different techniques such as differential scanning calorimetric (DSC) study, infra-red (IR) spectrophotometric study and isothermal stress testing were adopted. The results of DSC study showed that magnesium stearate exhibited some interaction with nateglinide. However, the results of IR, and IST studies showed that all the excipients used in the formula were compatible with nateglinide. Optimized formulations developed using the compatible excipients were found to be stable over 3 months of accelerated stability studies (40 ± 2 C and 75 ± 5 % RH). Overall, compatibility of excipients with nateglinide was successfully evaluated using a combination of thermal and IST methods and the formulations developed using the compatible excipients were found to be stable.

Keywords
nateglinide; immediate release tablet; drug-excipient interaction

Hrčak ID: 66187

URI
https://hrcak.srce.hr/66187

[croatian]

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