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Review article

Are mice, rats, and rabbits good models for physiological, pharmacological and toxicological studies in humans?

IVAN SABOLIĆ   ORCID icon orcid.org/0000-0002-2587-9109 ; Unit of Molecular Toxicology Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10001 Zagreb, Croatia
DAVORKA BRELJAK ; Unit of Molecular Toxicology Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10001 Zagreb, Croatia
MARIJA LJUBOJEVIĆ ; Unit of Molecular Toxicology Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10001 Zagreb, Croatia
HRVOJE BRZICA ; Unit of Molecular Toxicology Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10001 Zagreb, Croatia

Fulltext: english, pdf (278 KB) pages 7-16 downloads: 5.820* cite
APA 6th Edition
SABOLIĆ, I., BRELJAK, D., LJUBOJEVIĆ, M. & BRZICA, H. (2011). Are mice, rats, and rabbits good models for physiological, pharmacological and toxicological studies in humans?. Periodicum biologorum, 113 (1), 7-16. Retrieved from https://hrcak.srce.hr/67230
MLA 8th Edition
SABOLIĆ, IVAN, et al. "Are mice, rats, and rabbits good models for physiological, pharmacological and toxicological studies in humans?." Periodicum biologorum, vol. 113, no. 1, 2011, pp. 7-16. https://hrcak.srce.hr/67230. Accessed 22 Oct. 2021.
Chicago 17th Edition
SABOLIĆ, IVAN, DAVORKA BRELJAK, MARIJA LJUBOJEVIĆ and HRVOJE BRZICA. "Are mice, rats, and rabbits good models for physiological, pharmacological and toxicological studies in humans?." Periodicum biologorum 113, no. 1 (2011): 7-16. https://hrcak.srce.hr/67230
Harvard
SABOLIĆ, I., et al. (2011). 'Are mice, rats, and rabbits good models for physiological, pharmacological and toxicological studies in humans?', Periodicum biologorum, 113(1), pp. 7-16. Available at: https://hrcak.srce.hr/67230 (Accessed 22 October 2021)
Vancouver
SABOLIĆ I, BRELJAK D, LJUBOJEVIĆ M, BRZICA H. Are mice, rats, and rabbits good models for physiological, pharmacological and toxicological studies in humans?. Periodicum biologorum [Internet]. 2011 [cited 2021 October 22];113(1):7-16. Available from: https://hrcak.srce.hr/67230
IEEE
I. SABOLIĆ, D. BRELJAK, M. LJUBOJEVIĆ and H. BRZICA, "Are mice, rats, and rabbits good models for physiological, pharmacological and toxicological studies in humans?", Periodicum biologorum, vol.113, no. 1, pp. 7-16, 2011. [Online]. Available: https://hrcak.srce.hr/67230. [Accessed: 22 October 2021]

Abstracts
In the mammalian kidneys, handling of various organic compounds is
mediated by multispecific organic anion and cation transporters localized in the luminal and contraluminal cell membrane domains of specific nephron segments, largely in proximal tubules. These transporters are responsible for cellular uptake and/or elimination of endogenous and xenobiotic organic compounds, including various anionic and cationic drugs, thus contributing to their reabsorption and/or secretion along the nephron. Recent studies have indicated a pivotal role of these transporters in drug resistance, drug-drug interactions, and drug-induced nephrotoxicity, whereas the presence of disfunctional transporters due to truncated isoforms or point
mutations can cause genetic diseases. In rat, mouse and rabbit nephrons, a number of these transporters exhibit sex differences in their protein and/or mRNA expression. In comparison with the expression in rodents and rabbits, in the human nephrons some transporters are absent, some exhibit different localization in the cell membrane domains, and none exhibit the sex-dependent expression. Species differences in some transporters have been further demonstrated concerning substrate selectivity, distribution in cells along the nephron, levels of mRNA and/or protein expression, sensitivity to inhibitors, and regulation. Overall these differences in the mammalian kidneys indicate that: a) data on the membrane transporters-related functions in one species can not simply be regarded as relevant for other species, and b) many physiological, pharmacological, and toxicological findings related to organic anion and cation transport and transporters in rodents and rabbits
do not reflect the situation in humans.

Keywords
experimental animals; gender differences; mammalian kidney; nephrotoxicity; organic anions; organic cations; proximal tubule

Hrčak ID: 67230

URI
https://hrcak.srce.hr/67230

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