Original scientific paper
https://doi.org/10.22514/SV141.042018.11
Te signifcance of sTREM-1 as a diagnostic biomarker of sepsis in the context of Sepsis-3 definition
DUNJA MIHAJLOVIC
orcid.org/0000-0002-0607-0611
; Faculty of Medicine, University of Novi Sad Clinical Center of Vojvodina Emergency center, Department of anesthesia and reanimation Novi Sad, Hajduk Veljkova 1-3 Novi Sad, Serbia
VEDRANA PETRIC
SNEZANA BRKIC
DAJANA LENDAK
ALEKSANDRA NOVAKOV MIKIC
SLOBODANKA LEMAJIC KOMAZEC
Abstract
Aim. Sepsis remains the leading cause of
mortality in spite of advanced diagnostics.
Te aim of the study was to test the diagnostic
value of soluble triggering receptor
expressed on myeloid cells-1 (sTREM-1)
in the context of a new defnition of sepsis.
Methods. Te study was conducted on 41
patients who were suspected of having sepsis
according to SIRS (Systemic Infammatory
Response Syndrome) criteria or sterile
SIRS. 20 healthy volunteer blood donors
were the control group (adult patients of
both sexes). According to the latest sepsis
criteria (Sepsis-3), patients were retrospectively
divided into three subgroups: septic
patients, patients with SIRS plus infection
and patients with sterile SIRS (non-infectious
SIRS).
All subjects had concentrations of
sTREM-1 determined by the ELISA method
(Abcam commercial test, Cambridge,
MA, USA). Samples were collected upon
admission to hospital and kept at -20°C
until laboratory analysis was performed.
Results. Concentrations of sTREM-1 were
signifcantly increased in patients, compared
to the healthy population (p=0.021),
but there were no signifcant diferences
among subgroups of patients (SIRS plus
infection vs. sepsis p=0.871, SIRS plus infection
vs. sterile SIRS p=0.72, sepsis vs.
sterile SIRS p=0.65).
Te value of 300pg/mL was determined to
be the optimal cut-of. Concentrations of
sTREM-1 were signifcantly higher in septic
patients who did not develop Multiple
Organ Dysfunction Syndrome (MODS)
within the frst 48 hours afer admission
than in those who did.
Conclusion. According to our results,
sTREM-1 failed to express signifcance as
a diagnostic biomarker of sepsis, according
to the new defnition. Also, it seems not to
be a valuable marker in diferentiation of
sepsis and non-infective SIRS.
Keywords
Hrčak ID:
200439
URI
Publication date:
1.6.2018.
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