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eng Synthesis and Biological Evaluation of Indolyl Bis-chalcones as Anti-Breast Cancer and Antioxidant Agents
Bhale, Pravin S.; Chavan, Hemant V.; Endait, Rupali S.; Kadam, Ashok T.; Bopalkar, Rajesh J.; Gaikwad, Mandar S.
Croatica Chemica Acta Vol. 94, No. 1, 2021
A series of novel α-cyano substituted indolyl bis-chalcones (3a−l) has been synthesized and evaluated for their in vitro antitumor activity against the human breast cancer MCF7 (estrogen receptor-positive) and normal Vero cell lines using sulforhodamine B (SRB) assay method. Compounds 3a, 3c and 3d showed potent activity (GI50 = 11.7, 15.3 and 17.9 µM respectively) against the human breast cancer MCF7 cell line, which was almost as good as that of adriamycin (GI50 = < 0.1 µM) whereas, screening against the normal Vero Monkey cell line showed mo...
Hrčak ID: 269952


eng A Novel Class of Pyrazoline Analogue of Combretastatin-A4 (CA-4): Synthesis Characterization and in-vitro Biological Testing
Shringare, Sadanand N.; Bhale, Pravin S.; Chavan, Hemant V.; Hundekari, Purva L.; Kulkarni, Makarand A.
Croatica Chemica Acta Vol. 94, No. 4, 2021
A series of pyrazoline bridged combretastatin analogues were designed and synthesised from their precursor chalcone analogues, and all these compounds were ascertained by IR, 1H NMR, and mass spectral analysis. Subsequently, all these compounds were evaluated for anticancer activities against breast cancer (MCF-7) and normal Vero (Monkey Kidney) cell lines, and five selected compounds from the series were evaluated against Hela (Human Cervical), MDA-MB-231 (Breast), and A-549 (Lung cancer) cell lines using the Sulforhodamine B (SRB) assay metho...
Hrčak ID: 281184