Cervical cancer is the second most common female malignancy in Serbia, after breast cancer, with 1089 new registered
cases and an age-standardized incidence rate of 27.2 per 100,000 women in 2002. It is the fourth leading cause of
cancer death with 452 deaths and an age-standardized death rate of 7.2 per 100,000 women. Compared with other European
countries, the incidence of cervical cancer in Central Serbia is the highest. Regional differences in incidence are
pronounced in Serbia with the lowest age-standardized incidence rate (16.6 per 1...
In Croatia, there are about 355 incident cases and about 100 deaths from cervical cancer every year. The aim of this
study is to present the trends of cervical cancer incidence and mortality and to propose preventive strategies for cervical
cancer in Croatia. Age-standardised and age-specific cervical cancer incidence rates were calculated for the period
1985–2004. For cervical cancer mortality data, the WHO Mortality Database was used. After an early decrease of cervical
cancer incidence and mortality following the introduction of opportun...
Cervical cancer remains a significant source of disease and death in Europe. However, we now have the means to prevent
virtually every case of cervical cancer through comprehensive, population-based, organised cervical cancer prevention
programmes that effectively integrate cervical screening with the new technologies and vaccines that are now available.
Given the potential health benefits of these programmes in reducing disease incidence and mortality, their establishment
is now an ethical imperative for all European countries.
In Slovenia, opportunistic screening was introduced in regular gynaecological practice in 1960. The proportion of
population screened was unknown, as well as there were no standards for quality assurance and control. Despite great
number of smears read, there were no major changes in invasive cervical cancer incidence in the period 1979 till 1993,
but in 1994 the incidence rate started to increase again to reach its peak in 1997 (23,1/100.000, 241 new cases). Based on
the experiences from the countries with effectively organised screening p...
Introduction: Cervical cancer is one of the most common malignant tumors of the female reproductive system in women between 15-35 years of age. It takes third place in the frequency of all reproductive system cancers in Croatia. The aim of the present study was to analyze prognostic factors influencing on reccurence to improve therapeutic management.
Materials and Methods: We reviewed medical records and pathological materials obtained from 61 patients with stage IA2-IB2 between 2003 and 2013. The comparison of women with and without recurrenc...
Villoglandular papillary adenocarcinoma (VGA) of cervix is an uncommon but well recognized histologic subtype of cervical adenocarcinoma which usually affects young women. Based on the favorable outcomes reported in most previous cases the tumor is generally considered to have an indolent clinical course with excellent prognosis. We present a case of a 22-year-old woman admitted at our Department for glandular abnormality on cervical smear and episodes of vaginal discharge. In the Pap smear, the cytological features were suspicious but not diag...
The most commonly used staging system for cervical cancer is based on the International Federation of Gynaecology and Obstetrics (FIGO) staging system.Magnetic resonance imaging (MRI) has been accepted as the optimal tool for evaluation of the main prognostic factors and selection of therapeutic strategy. The purpose of this study was to compare the preoperative clinical examination FIGO staging findings with MRI and postoperative pathology report in females with primary cancer of the cervix. The study prospectively included 46 females consecut...
Since several years it has been accepted that persistent infection with certain (so called-high risk: HR) types of Human
papillomaviruses (HPV) represents a strong risk factor for cervical cancer. The most frequent HR HPV types 16 and 18
account for about 70% of this tumour, which is the second most frequent malignancy in women worldwide. Several studies
in animal papillomavirus models revealed that protection against infection is conferred by neutralizing antibodies
directed against conformational epitopes of the major structural protein L...
The results of the analysis of the treatment of 72 patients with carcinoma of the uterine cervix are presented. Seventy-
two patients with Stage IB1 carcinoma of the cervix underwent a radical hysterectomy and pelvic lymphadenectomy.
The low-risk group includes the patients without unfavourable prognostic factors that were treated by surgery
alone. The high-risk group included women with pelvic node metastases, clinical tumour size greater than 3.0 cm, depth
of stromal invasion greater than 1/3 of the cervical wall, Grade 3 tumours and the...
Effective primary and secondary cancer prevention programmes are key to improve public health. Cervical cancer is
preventable if high quality screening programmes, diagnosis and treatment are offered to female populations at high
coverage. Nevertheless, it continues to be a public health problem, and screening programmes need improvements. Human
papillomavirus (HPV) has been firmely established as the necessary cause of virtually all cervical cancer cases. To
date we count two clinically validated and approved HPV technologies, available to...