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eng A Novel Class of Pyrazoline Analogue of Combretastatin-A4 (CA-4): Synthesis Characterization and in-vitro Biological Testing
Shringare, Sadanand N.; Bhale, Pravin S.; Chavan, Hemant V.; Hundekari, Purva L.; Kulkarni, Makarand A.
Croatica Chemica Acta Vol. 94, No. 4, 2021
A series of pyrazoline bridged combretastatin analogues were designed and synthesised from their precursor chalcone analogues, and all these compounds were ascertained by IR, 1H NMR, and mass spectral analysis. Subsequently, all these compounds were evaluated for anticancer activities against breast cancer (MCF-7) and normal Vero (Monkey Kidney) cell lines, and five selected compounds from the series were evaluated against Hela (Human Cervical), MDA-MB-231 (Breast), and A-549 (Lung cancer) cell lines using the Sulforhodamine B (SRB) assay metho...
Hrčak ID: 281184


eng Synthesis and Pharmacological Evaluation of Pyrazoline and Pyrimidine Analogs of Combretastatin-A4 as Anticancer, Anti-inflammatory and Antioxidant Agents
Shringare, Sadanand N.; Chavan, Hemant V.; Bhale, Pravin S.; Dongare, Sakharam B.; Mule, Yoginath B.; Kolekar, Nishikant D.; Bandgar, Babasaheb P.
Croatica Chemica Acta Vol. 91, No. 3, 2018
A library of 3,5-diaryl-1-carbothioamide-pyrazoline (5a–j), N1-phenyl sulfonyl pyrazoline (6a–e) and pyrimidine (7a) analogs of combretastatin-A4 were synthesized and evaluated for their in vitro anticancer, anti-inflammatory and antioxidant activity. Results of in vitro assay against human breast cancer cell line (MCF-7) showed several compounds endowed with significant cytotoxicity compared to the adriamycin, a standard anticancer drug. Among the compounds synthesized, 7a was found to possess significant antiproliferative activity (GI50 < 0.1...
Hrčak ID: 207801


eng Synthesis, Crystal Structure and <i>in vitro</i> DNA Binding Studies of Combretastatin A-4 Analogue
Rizvi, Masood Ahmad; Dangat, Yuvraj; Yaseen, Zahid; Gupta, Vivek; Khan, Khaliquz Zaman
Croatica Chemica Acta Vol. 88, No. 3, 2015
Synthesis of a novel Combretastatin A-4 analogue using Schiff’s reaction of benzil and 4-aminoantipyrine has been achieved under solvent free conditions. The structure of compound was examined spectroscopically and confirmed from single crystal diffraction studies. The synthesized Combretastatin A-4 analogue was investigated for its DNA binding ability as the plausible mechanism for its antitumor activity. The binding propensity of the synthesized compound with calf-thymus (CT) DNA was monitored with absorption and emission spectrophotometric t...
Hrčak ID: 150534