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eng A Novel Class of Pyrazoline Analogue of Combretastatin-A4 (CA-4): Synthesis Characterization and in-vitro Biological Testing
Shringare, Sadanand N.; Bhale, Pravin S.; Chavan, Hemant V.; Hundekari, Purva L.; Kulkarni, Makarand A.
Croatica Chemica Acta Vol. 94, No. 4, 2021
A series of pyrazoline bridged combretastatin analogues were designed and synthesised from their precursor chalcone analogues, and all these compounds were ascertained by IR, 1H NMR, and mass spectral analysis. Subsequently, all these compounds were evaluated for anticancer activities against breast cancer (MCF-7) and normal Vero (Monkey Kidney) cell lines, and five selected compounds from the series were evaluated against Hela (Human Cervical), MDA-MB-231 (Breast), and A-549 (Lung cancer) cell lines using the Sulforhodamine B (SRB) assay metho...
Hrčak ID: 281184

eng Effects of host defense peptides B2RP, Brevinin-2GU, D-Lys-Temporin, Lys-XT-7 and D-Lys-Ascaphin-8 on peripheral blood mononuclear cells: Preliminary study
Popovic, Suzana; Djurdjevic, Predrag; Zaric, Milan; Mijailovic, Zeljko; Avramovic, Dusko; Baskic, Dejan
Periodicum biologorum Vol. 119, No. 2, 2017
<p><strong><em>Background and purpose</em></strong>: Host defense peptides have considerable therapeutic potential. One of the limitations for their therapeutic use is insufficient selectivity of some peptides, i.e. toxicity for eukaryotic cells. In this study, we have investigated effect of two naturally occurring and three analogs of frog skin-derived peptides on viability/proliferation of resting peripheral blood mononuclear cells and activated lymphocytes.</p><p><strong><em>Materials and Methods</em></strong>: Effect of tested peptides was...
Hrčak ID: 185861

eng Eosinophil catonic protein – current concepts and controversies
Zrinski Topic, Renata
Biochemia Medica Vol. 21, No. 2, 2011
Eosinophil cationic protein (ECP) is a heterogeneous molecule originating from activated eosinophil granulocytes. Biological activity and the cellular content of ECP are determined by genetic and pos-ttranslational factors. Several single nucleotide polymorphisms (SNPs) in human ECP gene (RNASE3) have been described so far. ECP is a mediator in host immune response to parasites, bac-teria and viruses. By its cytotoxic and non-cytotoxic activity, ECP may also cause side-effects in the host’s own tissues. The largest number of clinical studies is...
Hrčak ID: 69653

eng Cytotoxicity of Selected Pyridinium Oximes in Human SH-SY5Y Neuroblastoma Cell Line
Kalanj Bognar, Svjetlana; Foretić, Blaženka; Vukelić, Željka; Gulin, Tonko; Ježek, Davor
Croatica Chemica Acta Vol. 81, No. 1, 2008
Pyridinium oximes are pharmacologically important nucleophylic agents acting as effective antidotes against poisoning by organophosphorus compounds that inhibit acetylcholinesterase (AChE; EC In this study, the cytotoxicity of 1-phenacylpyridinium-4-aldoxime chloride (FEPA-4) was analyzed in human SH-SY5Y neuroblastoma cell line highly expressing acetylcholinesterase. The concentrations of 0.5, 1, 2 and 4 mmol dm–3 and time-dependent effects at 1, 3, 6, 12 and 24 hours were tested in comparison with non-treated cells. In addition, ne...
Hrčak ID: 23392

eng Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives
Acta Pharmaceutica Vol. 63, No. 2, 2013
Synthesis and biological evaluation for a series (N = 16) of cyclic and acyclic hydroxyurea derivatives including benzotriazole-, isocyanuirc acid- and biuret-containing compounds, are disclosed. 1-N-(benzyloxycarbamoyl)benzotriazole was used as benzyloxyisocyanate donor, a useful intermediate in the preparation of substituted hydroxyurea. Antibacterial activities of synthesized hydroxyurea derivatives were tested on three E. coli strains, i.e., strain susceptible to antibiotics, strain resistant to macrolide antibiotics and strain resistant to...
Hrčak ID: 97696

eng Bone-Mimicking Injectable Gelatine/Hydroxyapatite Hydrogels
Rogina, A.; Šandrk, N.; Teruel-Biosca, L.; Antunović, M.; Ivanković, M.; Gallego Ferrer, G.
Bioactive synthetic hydrogels have emerged as promising materials because they can provide molecularly tailored biofunctions and adjustable mechanical properties. To mimic the mineralogical and organic components of the natural bone, hydroxyapatite and a tyramine conjugate of gelatine were combined in this study. The effect of various amounts of in situ synthesized hydroxyapatite in gelatine-tyramine on the morphology and physical properties of injectable hydrogels was investigated. Mineralogical identification confirmed successful precipitat...
Hrčak ID: 225896

eng In vitro Evaluation of Aldoxime Interactions with Human Acetylcholinesterase
Kovarik, Zrinka; Čalić, Maja; Bosak, Anita; Šinko, Goran; Jelić, Dubravko
Croatica Chemica Acta Vol. 81, No. 1, 2008
We related the ability of eleven pyridinium and imidazolium aldoximes to reactivate tabun-inhibited human erythrocyte acetylcholinesterase with their molecular properties. Using molecular mechanics we performed conformational analysis to determine the flexibility of the aldoximes. Semi-empirical calculations show that differences in reactivation rates probably do not origin from different electron density on the oxygen of the oxime group, but can be explained by the steric hindrance within the aldoxime molecule. Tabun-inhibited acetylcholineste...
Hrčak ID: 23385

eng Flow Cytometric Analysis of the Influence of Myosmine on the Cell Cycle
Boteva, Borislava I.; Mateva, Rada M.; Iliev, Ivan A.; Gorneva, Galina A.
Croatica Chemica Acta Vol. 84, No. 3, 2011
Myosmine (3-(1-pyrrolin-2-yl)pyridine) is an alkaloid found in tobacco as well as various staple foods, fruits and vegetables. Myosmine has recently been suspected to be a tobacco-independent carcinogenic source. Using cell flow cytometry, we have examined the influence of myosmine on the cell cycle of murine erythroleukemia (MEL) cells in vitro and have compared this with its effects on murine bone marrow cells in vivo. Myosmine at low concentrations inhibited cell proliferation dose dependently; while at concentrations close to 300 μmol...
Hrčak ID: 74772

eng Behaviour of 9-Ethyl-9H-carbazole Hydrazone Derivatives Against Oxidant Systems: Protective Effect on Amyloid β-Induced Damage
Karaaslan, Cigdem; Ince, Elif; Gurer-Orhan, Hande; Tavakkoli, Marjan; Firuzi, Omidreza; Saso, Luciano; Suzen, Sibel
Croatica Chemica Acta Vol. 92, No. 1, 2019
Antioxidants are helpful in prevention of several diseases related with oxidative stress including neurodegenerative disorders. In recent studies, carbazoles were given proof of promising antioxidant activities. In this article, 9-ethyl-9H-carbazole hydrazone derivatives were synthesized, characterized and their in vitro antioxidant activity and possible cytotoxic effects were investigated. Furthermore, protective effect of the synthesized derivatives against amyloid β-induced damage in PC12 neuronal cells was examined by using MTT assay. The n...
Hrčak ID: 221311

eng Immunomodulation of Cell-Mediated Cytotoxicity after Chronic Exposure to Vapors
Bulog, Aleksandar; Brčić Karačonji, Irena; Šutić, Ivana; Mićović, Vladimir
Collegium antropologicum Vol. 35 - supplement 2, No. 2, 2011
Cytotoxic T lymphocytes and natural killer (NK) cells represent two major types of immune cytotoxic cells that have a crucial role in innate immunity. Urban air pollution represents a common and difficult problem in the majority of metropolises, which contain high levels of trafficcongestion generating great amounts of genotoxic substances. Diesel exhaust particles act as adjuvant in the immune response and may lead to the enhancement of proinflammatory and proallergic response without exposure to allergen. The activities of diesel exhaust...
Hrčak ID: 72227