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Godini

eng A Novel Class of Pyrazoline Analogue of Combretastatin-A4 (CA-4): Synthesis Characterization and in-vitro Biological Testing
Shringare, Sadanand N.; Bhale, Pravin S.; Chavan, Hemant V.; Hundekari, Purva L.; Kulkarni, Makarand A.
Croatica Chemica Acta Vol. 94, No. 4, 2021
A series of pyrazoline bridged combretastatin analogues were designed and synthesised from their precursor chalcone analogues, and all these compounds were ascertained by IR, 1H NMR, and mass spectral analysis. Subsequently, all these compounds were evaluated for anticancer activities against breast cancer (MCF-7) and normal Vero (Monkey Kidney) cell lines, and five selected compounds from the series were evaluated against Hela (Human Cervical), MDA-MB-231 (Breast), and A-549 (Lung cancer) cell lines using the Sulforhodamine B (SRB) assay metho...
Hrčak ID: 281184


eng Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents
AJANI, OLAYINKA O.; NLEBEMUO, MARTINS T.; ADEKOYA, JOSEPH A.; OGUNNIRAN, KEHINDE O.; SIYANBOLA, TOLUTOPE O.; AJANAKU, CHRISTIANA O.
Acta Pharmaceutica Vol. 69, No. 2, 2019
Surpassing heart diseases, cancer is taking the lead as the deadliest disease because of its fast rate of spreading in all parts of the world. Tireless commitment to searching for novel therapeutic medicines is a worthwhile adventure in synthetic chemistry because of the drug resistance predicament and regular outbreak of new diseases due to abnormal cell growth and proliferation. Medicinal chemistry researchers and pharmacists have unveiled quinoxaline templates as precursors of importance and valuable intermediates in drug discovery because t...
Hrčak ID: 217779


eng Synthesis of Novel Benzamide- piperazine-sulfonamide Hybrids as Potential Anticancer Agents
Ramalingeswara Rao, B.; Rao Katiki, Mohana; Kommula, Dileep; Narayanan, SaiShyam; Anto, Ruby John; Murty, M. S. R.
Croatica Chemica Acta Vol. 92, No. 3, 2019
The synthesis of a series of substituted hippuric acid (2-benzamidoacetic acid) derivatives containing arylsulfonylpiperazine nucleus (3a–j, 4a–j) is described. The compounds were synthesized by coupling hippuric/4-fluorohippuric acid with various arylsulfonylpiperazines using N-(3-dimethylaminopropyl)-N-ethylcarbodiimide (EDCI). The structures of all the new compounds were confirmed by IR, NMR and MS spectral data. All the synthesized compounds have been evaluated for their in vitro cytotoxicity towards five human cancer cell lines of differen...
Hrčak ID: 226910


eng Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs
TORIĆ, JELENA; KARKOVIĆ MARKOVIĆ, ANA; JAKOBUŠIĆ BRALA, CVIJETA; BARBARIĆ, MONIKA
Acta Pharmaceutica Vol. 69, No. 4, 2019
Cancer presents one of the leading causes of death in the world. Current treatment includes the administration of one or more anticancer drugs, commonly known as chemotherapy. The biggest issue concerning the chemotherapeutics is their toxicity on normal cells and persisting side effects. One approach to the issue is chemoprevention and the other one is the discovery of more effective drugs or drug combinations, including combinations with polyphenols. Olive oil polyphenols (OOPs), especially hydroxytyrosol (HTyr), tyrosol (Tyr) and their deriv...
Hrčak ID: 225431


eng Synthesis, in vitro anticancer and antioxidant activity of thiadiazole substituted thiazolidin-4-ones
JOSEPH, ALEX; SHAH, CHAITANYAKUMAR S.; KUMAR, SUTHAR SHARAD; ALEX, ANGEL TREASA; MALIYAKKAL, NASEER; MOORKOTH, SUDHEER; MATHEW, JESSY ELIZABETH
Acta Pharmaceutica Vol. 63, No. 3, 2013
A series of novel 5-alkyl/aryl thiadiazole substituted thiazolidin-4-ones were synthesized by a two-step process. In the first step, 5-alkyl/aryl substituted 2-amino-thiadiazoles were synthesized, which on reaction with substituted aromatic aldehydes and thioglycolic acid in presence of dicyclohexylcarbodiimide afforded thiazolidin-4-ones. All compounds were synthesized in fairly good yields and their structures were confirmed by spectral and physical data. The title compounds were screened for in vitro anti-proliferative activity on human brea...
Hrčak ID: 102031


eng Synthesis of New Azoles and Azolopyrimidines Incorporating Morpholine Moiety as Potent Anti-Tumor Agents
Gomha, Sobhi M.; Muhammad, Zeinab A.; Abdel-aziz, Hassan M.; El-Arab, Elham Ezz
Croatica Chemica Acta Vol. 91, No. 1, 2018
A new series of morpholinyl-chalcones 2a–d was prepared by reaction of 2-oxo-N,4-diarylbut-3-enehydrazonoyl chlorides 1a–d with morpholine. These chalcones were used as a building block for constructing pyrazoles 3a–d and 3,4-dihydropyrimidine-2(1H)-thione 6 via their reaction with phenylhydrazine and thiourea, respectively. Moreover, a new series of azolopyrimidine derivatives 11a,b, 15, 17, 19, and 21 incorporating morpholine moiety were synthesized by reaction of 1-morpholino-4-phenyl-1-(2-phenylhydrazono)but-3-en-2-one (2a) with a number of...
Hrčak ID: 197637


eng The antitumor activity of umbelliferone in human renal cell carcinoma via regulation of the p110γ catalytic subunit of PI3Kγ
WANG, XUE; HUANG, SHUAISHUAI; XIN, XIA; REN, YU; WENG, GOUBIN; WANG, PING
Acta Pharmaceutica Vol. 69, No. 1, 2019
Umbelliferone exhibits extensive pharmacological activity, including anti-immunomodulatory, anti-inflammatory and antigenotoxicity activities. However, its antitumor properties still remain unclear in human renal cell carcinoma (RCC) cells. Our results have revealed that treatment of human RCC cells (786-O, OS-RC-2, and ACHN) with umbelliferone reduced cell proliferation in a concentration-dependent manner and induced dose-dependent apoptotic events. In addition, cell cycle analysis determined that umbelliferone treatment induced cell cycle arr...
Hrčak ID: 206649


eng Synthesis and Pharmacological Evaluation of Pyrazoline and Pyrimidine Analogs of Combretastatin-A4 as Anticancer, Anti-inflammatory and Antioxidant Agents
Shringare, Sadanand N.; Chavan, Hemant V.; Bhale, Pravin S.; Dongare, Sakharam B.; Mule, Yoginath B.; Kolekar, Nishikant D.; Bandgar, Babasaheb P.
Croatica Chemica Acta Vol. 91, No. 3, 2018
A library of 3,5-diaryl-1-carbothioamide-pyrazoline (5a–j), N1-phenyl sulfonyl pyrazoline (6a–e) and pyrimidine (7a) analogs of combretastatin-A4 were synthesized and evaluated for their in vitro anticancer, anti-inflammatory and antioxidant activity. Results of in vitro assay against human breast cancer cell line (MCF-7) showed several compounds endowed with significant cytotoxicity compared to the adriamycin, a standard anticancer drug. Among the compounds synthesized, 7a was found to possess significant antiproliferative activity (GI50 < 0.1...
Hrčak ID: 207801


eng Adjuvant Cancer Biotherapy by Viscum Album Extract Isorel: Overview of Evidence Based Medicine Findings
Borovic Sunjic, Suzana; Cipak Gasparovic, Ana; Vukovic, Tea; Weiss, Thomas; Sussman Weiss, Elisabeth; Soldo, Ivo; Djakovic, Nikola; Zarkovic, Tomislav; Zarkovic, Neven
Collegium antropologicum Vol. 39, No. 3, 2015
Within the integrative medicine one of the most frequently used adjuvant cancer biotherapies is based on aqueous mistletoe (Viscum album) extracts. Tumor growth inhibition, stimulation of host immune response and improvement of the quality of life are the positive effects of mistletoe therapy described in several preclinical and clinical studies. However, cumulative results of the evidence based medicine findings on such treatments are rarely given. Therefore, this paper evaluates the evidence based findings describing effects of the Viscum alb...
Hrčak ID: 166282


eng Review of the Anticancer and Cytotoxic Activity of some Species from Genus Euphorbia
Aleksandrov, Mihail; Maksimova, Viktorija; Koleva Gudeva, Liljana
Euphorbiaceae is a widely spread family. To genus Euphorbia, from that family, belongs more than 2000 species. The plants of this genus have been used for a long time in traditional medicine. Their main active components: alkanes, triterpenes, phytosterols, tannins, polyphenols and flavanoids are supposed to be responsible for different types of activity. Euphorbia formosana Hayata is a medicinal plant used to treat rheumatism, liver cirrhosis, herpes zoster and it is used as tumor suppressor. Euphorbia tirucalli L. have been used to obtain met...
Hrčak ID: 218527